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Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile

For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (...

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Main Author: Contel, Maria
Format: Online
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2021
Subjects:
QH301-705.5
QD415-436
Q1-390
?–? stacking
encapsulation
n/a
oxindolimine–metal complexes
cyclodextrin
platinum iodido complexes
distribution coefficient
antiproliferative activity
anticancer agents
nanotubes
ruthenium
platinum
Log kw
nanoparticles
drug discovery
metal complex
metallodrugs
isatin-derived ligands
anticancer drug
upconverting nanoparticles
pyridine benzimidazole
dendrimers
liposomes
thiophene
angiogenesis
micelles
HSA oxidation
platinum(IV)
imaging
chromatographic lipophilicity parameter
amidophosphine
copper and iron chelators in cancer
Log P
biomacromolecules
bones
DNA cleavage
stopped-flow spectroscopy
silver
phosphonates
transmetalation
metallomics
MRI
fluorescence quenching
partition coefficient
gold fingers
anticancer
HSA binding
gold
?0
targeting
metastasis
DNA interaction
antimigration
cytotoxicity
HPLC
ruthenium complexes
zinc finger proteins
Gold(III) complexes
aquaporins
antiproliferative
protein-DNA recognition
photoactivation
lipophilicity
cancer
1-methylcytosine
PET
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online Access:42560
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