Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile
For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (...
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| Hōputu: | Online |
| Reo: | Ingarihi |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Ngā marau: | |
| Urunga tuihono: | 42560 |
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Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869527044072669184 |
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| author | Contel, Maria |
| author_browse | Contel, Maria |
| author_facet | Contel, Maria |
| author_sort | Contel, Maria |
| collection | Directory of Open Access Books |
| description | For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile. |
| format | Online |
| id | doab-20.500.12854ir-61518 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-615182024-04-05T12:33:19Z Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile Contel, Maria QH301-705.5 QD415-436 Q1-390 ?–? stacking encapsulation n/a oxindolimine–metal complexes cyclodextrin platinum iodido complexes distribution coefficient antiproliferative activity anticancer agents nanotubes ruthenium platinum Log kw nanoparticles drug discovery metal complex metallodrugs isatin-derived ligands anticancer drug upconverting nanoparticles pyridine benzimidazole dendrimers liposomes thiophene angiogenesis micelles HSA oxidation platinum(IV) imaging chromatographic lipophilicity parameter amidophosphine copper and iron chelators in cancer Log P biomacromolecules bones DNA cleavage stopped-flow spectroscopy silver phosphonates transmetalation metallomics MRI fluorescence quenching partition coefficient gold fingers anticancer HSA binding gold ?0 targeting metastasis DNA interaction antimigration cytotoxicity HPLC ruthenium complexes zinc finger proteins Gold(III) complexes aquaporins antiproliferative protein-DNA recognition photoactivation lipophilicity cancer 1-methylcytosine PET thema EDItEUR::P Mathematics and Science::PS Biology, life sciences For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile. 2021-02-12T06:53:10Z 2021-02-12T06:53:10Z 2019-12-09 11:49:15 2019 book 42560 9783039213160 9783039213153 https://directory.doabooks.org/handle/20.500.12854/61518 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1637 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-316-0 10.3390/books978-3-03921-316-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039213160 9783039213153 204 open access |
| spellingShingle | QH301-705.5 QD415-436 Q1-390 ?–? stacking encapsulation n/a oxindolimine–metal complexes cyclodextrin platinum iodido complexes distribution coefficient antiproliferative activity anticancer agents nanotubes ruthenium platinum Log kw nanoparticles drug discovery metal complex metallodrugs isatin-derived ligands anticancer drug upconverting nanoparticles pyridine benzimidazole dendrimers liposomes thiophene angiogenesis micelles HSA oxidation platinum(IV) imaging chromatographic lipophilicity parameter amidophosphine copper and iron chelators in cancer Log P biomacromolecules bones DNA cleavage stopped-flow spectroscopy silver phosphonates transmetalation metallomics MRI fluorescence quenching partition coefficient gold fingers anticancer HSA binding gold ?0 targeting metastasis DNA interaction antimigration cytotoxicity HPLC ruthenium complexes zinc finger proteins Gold(III) complexes aquaporins antiproliferative protein-DNA recognition photoactivation lipophilicity cancer 1-methylcytosine PET thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Contel, Maria Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile |
| title | Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile |
| title_full | Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile |
| title_fullStr | Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile |
| title_full_unstemmed | Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile |
| title_short | Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile |
| title_sort | unconventional anticancer metallodrugs and strategies to improve their pharmacological profile |
| topic | QH301-705.5 QD415-436 Q1-390 ?–? stacking encapsulation n/a oxindolimine–metal complexes cyclodextrin platinum iodido complexes distribution coefficient antiproliferative activity anticancer agents nanotubes ruthenium platinum Log kw nanoparticles drug discovery metal complex metallodrugs isatin-derived ligands anticancer drug upconverting nanoparticles pyridine benzimidazole dendrimers liposomes thiophene angiogenesis micelles HSA oxidation platinum(IV) imaging chromatographic lipophilicity parameter amidophosphine copper and iron chelators in cancer Log P biomacromolecules bones DNA cleavage stopped-flow spectroscopy silver phosphonates transmetalation metallomics MRI fluorescence quenching partition coefficient gold fingers anticancer HSA binding gold ?0 targeting metastasis DNA interaction antimigration cytotoxicity HPLC ruthenium complexes zinc finger proteins Gold(III) complexes aquaporins antiproliferative protein-DNA recognition photoactivation lipophilicity cancer 1-methylcytosine PET thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 QD415-436 Q1-390 ?–? stacking encapsulation n/a oxindolimine–metal complexes cyclodextrin platinum iodido complexes distribution coefficient antiproliferative activity anticancer agents nanotubes ruthenium platinum Log kw nanoparticles drug discovery metal complex metallodrugs isatin-derived ligands anticancer drug upconverting nanoparticles pyridine benzimidazole dendrimers liposomes thiophene angiogenesis micelles HSA oxidation platinum(IV) imaging chromatographic lipophilicity parameter amidophosphine copper and iron chelators in cancer Log P biomacromolecules bones DNA cleavage stopped-flow spectroscopy silver phosphonates transmetalation metallomics MRI fluorescence quenching partition coefficient gold fingers anticancer HSA binding gold ?0 targeting metastasis DNA interaction antimigration cytotoxicity HPLC ruthenium complexes zinc finger proteins Gold(III) complexes aquaporins antiproliferative protein-DNA recognition photoactivation lipophilicity cancer 1-methylcytosine PET thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 42560 |
| work_keys_str_mv | AT contelmaria unconventionalanticancermetallodrugsandstrategiestoimprovetheirpharmacologicalprofile |