Ubiquitin
The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain...
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| Format: | Online |
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| Sprache: | Englisch |
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IntechOpen
2021
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| Online-Zugang: | ONIX_20210420_9781838808419_3139 |
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| description | The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases. |
| format | Online |
| id | doab-20.500.12854ir-67779 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-677792024-04-05T17:30:52Z Ubiquitin Zhan, Xianquan Proteins thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases. 2021-04-20T16:25:33Z 2021-04-20T16:25:33Z 2020 book ONIX_20210420_9781838808419_3139 2632-0983 9781838808419 9781838804329 9781838808426 https://directory.doabooks.org/handle/20.500.12854/67779 eng Biochemistry image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/9742/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.87547 10.5772/intechopen.87547 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781838808419 9781838804329 9781838808426 IntechOpen 18 124 open access |
| spellingShingle | Proteins thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Ubiquitin |
| title | Ubiquitin |
| title_full | Ubiquitin |
| title_fullStr | Ubiquitin |
| title_full_unstemmed | Ubiquitin |
| title_short | Ubiquitin |
| title_sort | ubiquitin |
| topic | Proteins thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | Proteins thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | ONIX_20210420_9781838808419_3139 |