Chapter Preparing Proteoforms of Therapeutic Proteins for Top-Down Mass Spectrometry

A characteristic of many proteoforms, derived from a single gene, is their similarity regarding the composition of atoms, making their analysis very challenging. Many overexpressed recombinant proteins are strongly associated with this problem, especially recombinant therapeutic glycoproteins from l...

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Bibliographic Details

Main Authors:	Heikaus, Laura, Schlüter, Hartmut, Nurul Hidayah, Siti, Gaikwad, Manasi
Format:	Online
Language:	English
Published:	InTechOpen 2021
Subjects:	proteoforms, top-down mass spectrometry, therapeutic proteins, liquid chromatography, protein purification parameter screening, displacement chromatography thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
Online Access:	ONIX_20210602_10.5772/intechopen.89644_439
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