Asthma
Asthma is a common complex and heterogeneous respiratory disease with an increasing prevalence in developed countries. Asthma is a disease consisting of different phenotypes that are driven by different mechanistic pathways (endotypes). The recognition of these phenotypes and endotypes is central to...
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| Formaat: | Online |
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| Taal: | Engels |
| Gepubliceerd in: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Onderwerpen: | |
| Online toegang: | ONIX_20210501_9783039438594_22 |
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| _version_ | 1869530472413921280 |
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| collection | Directory of Open Access Books |
| description | Asthma is a common complex and heterogeneous respiratory disease with an increasing prevalence in developed countries. Asthma is a disease consisting of different phenotypes that are driven by different mechanistic pathways (endotypes). The recognition of these phenotypes and endotypes is central to asthma management entailing prognostic and therapeutic implications. It is acknowledged that despite optimal treatment, many patients are poorly controlled, highlighting the need for phenotype-guided treatments. In this context, the emergence of novel therapies (monoclonal antibody therapy, bronchial thermoplasty) is paving the way for personalized asthma therapy. A better understanding of disease pathogenesis may enable the identification of biomarkers, mediators, novel therapeutic targets, and treatable traits. Further molecular phenotyping or endotyping of asthma will be necessary to tailor new therapeutic strategies. The present Special Issue on Asthma aims to provide the current knowledge on phenotypes and endotypes in appreciating and managing the heterogeneous condition that is asthma. |
| format | Online |
| id | doab-20.500.12854ir-68279 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-682792024-03-31T13:10:13Z Asthma Rovina, Nikoletta asthma lactic acidosis hyperchloremic acidosis hypocapnia hypercapnia wheezing bronchial biopsies symptom persistence clinical remission eosinophil adhesion viability proliferation airway smooth muscle cell pulmonary fibroblast phenotype acute severe asthma exacerbation near fatal asthma severe asthma inflammation interleukin-5 (IL-5) anti-IL-5 interleukin-4 airway remodeling matrix metalloproteinases-9 tissue inhibitor of metalloproteinase-1 alveolar macrophages lung function bronchodilation resistance obstruction reproducible spirometry obstructive sleep apnea bronchial asthma alternative overlap syndrome exacerbation reactive oxygen species PBMC mitochondrial function innate immunity immune regulation NLRP3 IL-1β allergic airway inflammation microbiome pathogenesis immune responses PreDicta preschool FeNO asthma-specific quality of life chronic rhinitis disease-specific quality of life health-related quality of Life (HRQLQ) children longitudinal study thema EDItEUR::M Medicine and Nursing Asthma is a common complex and heterogeneous respiratory disease with an increasing prevalence in developed countries. Asthma is a disease consisting of different phenotypes that are driven by different mechanistic pathways (endotypes). The recognition of these phenotypes and endotypes is central to asthma management entailing prognostic and therapeutic implications. It is acknowledged that despite optimal treatment, many patients are poorly controlled, highlighting the need for phenotype-guided treatments. In this context, the emergence of novel therapies (monoclonal antibody therapy, bronchial thermoplasty) is paving the way for personalized asthma therapy. A better understanding of disease pathogenesis may enable the identification of biomarkers, mediators, novel therapeutic targets, and treatable traits. Further molecular phenotyping or endotyping of asthma will be necessary to tailor new therapeutic strategies. The present Special Issue on Asthma aims to provide the current knowledge on phenotypes and endotypes in appreciating and managing the heterogeneous condition that is asthma. 2021-05-01T15:06:01Z 2021-05-01T15:06:01Z 2021 book ONIX_20210501_9783039438594_22 9783039438594 9783039438600 https://directory.doabooks.org/handle/20.500.12854/68279 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3288 https://mdpi.com/books/pdfview/book/3288 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-860-0 10.3390/books978-3-03943-860-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039438594 9783039438600 280 Basel, Switzerland open access |
| spellingShingle | asthma lactic acidosis hyperchloremic acidosis hypocapnia hypercapnia wheezing bronchial biopsies symptom persistence clinical remission eosinophil adhesion viability proliferation airway smooth muscle cell pulmonary fibroblast phenotype acute severe asthma exacerbation near fatal asthma severe asthma inflammation interleukin-5 (IL-5) anti-IL-5 interleukin-4 airway remodeling matrix metalloproteinases-9 tissue inhibitor of metalloproteinase-1 alveolar macrophages lung function bronchodilation resistance obstruction reproducible spirometry obstructive sleep apnea bronchial asthma alternative overlap syndrome exacerbation reactive oxygen species PBMC mitochondrial function innate immunity immune regulation NLRP3 IL-1β allergic airway inflammation microbiome pathogenesis immune responses PreDicta preschool FeNO asthma-specific quality of life chronic rhinitis disease-specific quality of life health-related quality of Life (HRQLQ) children longitudinal study thema EDItEUR::M Medicine and Nursing Asthma |
| title | Asthma |
| title_full | Asthma |
| title_fullStr | Asthma |
| title_full_unstemmed | Asthma |
| title_short | Asthma |
| title_sort | asthma |
| topic | asthma lactic acidosis hyperchloremic acidosis hypocapnia hypercapnia wheezing bronchial biopsies symptom persistence clinical remission eosinophil adhesion viability proliferation airway smooth muscle cell pulmonary fibroblast phenotype acute severe asthma exacerbation near fatal asthma severe asthma inflammation interleukin-5 (IL-5) anti-IL-5 interleukin-4 airway remodeling matrix metalloproteinases-9 tissue inhibitor of metalloproteinase-1 alveolar macrophages lung function bronchodilation resistance obstruction reproducible spirometry obstructive sleep apnea bronchial asthma alternative overlap syndrome exacerbation reactive oxygen species PBMC mitochondrial function innate immunity immune regulation NLRP3 IL-1β allergic airway inflammation microbiome pathogenesis immune responses PreDicta preschool FeNO asthma-specific quality of life chronic rhinitis disease-specific quality of life health-related quality of Life (HRQLQ) children longitudinal study thema EDItEUR::M Medicine and Nursing |
| topic_facet | asthma lactic acidosis hyperchloremic acidosis hypocapnia hypercapnia wheezing bronchial biopsies symptom persistence clinical remission eosinophil adhesion viability proliferation airway smooth muscle cell pulmonary fibroblast phenotype acute severe asthma exacerbation near fatal asthma severe asthma inflammation interleukin-5 (IL-5) anti-IL-5 interleukin-4 airway remodeling matrix metalloproteinases-9 tissue inhibitor of metalloproteinase-1 alveolar macrophages lung function bronchodilation resistance obstruction reproducible spirometry obstructive sleep apnea bronchial asthma alternative overlap syndrome exacerbation reactive oxygen species PBMC mitochondrial function innate immunity immune regulation NLRP3 IL-1β allergic airway inflammation microbiome pathogenesis immune responses PreDicta preschool FeNO asthma-specific quality of life chronic rhinitis disease-specific quality of life health-related quality of Life (HRQLQ) children longitudinal study thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039438594_22 |