New Aspects of Cancer Stem Cell Biology
The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological charact...
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| Formato: | Online |
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| Idioma: | inglês |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Acesso em linha: | ONIX_20210501_9783039434060_1074 |
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| description | The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on “New aspects of cancer stem cell biology: implications for innovative therapies” aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies. |
| format | Online |
| id | doab-20.500.12854ir-69328 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-693282024-03-28T03:33:40Z New Aspects of Cancer Stem Cell Biology Cavallaro, Ugo Giordano, Marco Cadherin 11 WNT signaling β-catenin cancer stem cells TNBC early breast cancer bevacizumab neoadjuvant chemotherapy ALDH1 solid cancer chemo-resistance HDAC inhibitors head and neck squamous cell carcinoma SRC dasatinib saracatinib EC-8042 Ovarian cancer Wnt signaling tumor progression therapy resistance exosomes oral cancer risk oral epithelial dysplasia SOX2 immunohistochemistry oral squamous cell carcinoma genome-wide transcriptome lung cancer ATAC-seq RNA-seq CSCs NSCLC B4GALT1 LUAD breast cancer lipid metabolism therapeutic resistance bowel cancer organoid tumoroid colorectal colon stem cell chemotherapy resistance ovarian cancer cancer stem cell genetic heterogeneity SNP array L1CAM chemoresistance epithelial-mesenchymal transition cancer therapy cell adhesion molecule thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on “New aspects of cancer stem cell biology: implications for innovative therapies” aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies. 2021-05-01T15:46:49Z 2021-05-01T15:46:49Z 2020 book ONIX_20210501_9783039434060_1074 9783039434060 9783039434077 https://directory.doabooks.org/handle/20.500.12854/69328 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3120 https://mdpi.com/books/pdfview/book/3120 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-407-7 10.3390/books978-3-03943-407-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039434060 9783039434077 208 Basel, Switzerland open access |
| spellingShingle | Cadherin 11 WNT signaling β-catenin cancer stem cells TNBC early breast cancer bevacizumab neoadjuvant chemotherapy ALDH1 solid cancer chemo-resistance HDAC inhibitors head and neck squamous cell carcinoma SRC dasatinib saracatinib EC-8042 Ovarian cancer Wnt signaling tumor progression therapy resistance exosomes oral cancer risk oral epithelial dysplasia SOX2 immunohistochemistry oral squamous cell carcinoma genome-wide transcriptome lung cancer ATAC-seq RNA-seq CSCs NSCLC B4GALT1 LUAD breast cancer lipid metabolism therapeutic resistance bowel cancer organoid tumoroid colorectal colon stem cell chemotherapy resistance ovarian cancer cancer stem cell genetic heterogeneity SNP array L1CAM chemoresistance epithelial-mesenchymal transition cancer therapy cell adhesion molecule thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences New Aspects of Cancer Stem Cell Biology |
| title | New Aspects of Cancer Stem Cell Biology |
| title_full | New Aspects of Cancer Stem Cell Biology |
| title_fullStr | New Aspects of Cancer Stem Cell Biology |
| title_full_unstemmed | New Aspects of Cancer Stem Cell Biology |
| title_short | New Aspects of Cancer Stem Cell Biology |
| title_sort | new aspects of cancer stem cell biology |
| topic | Cadherin 11 WNT signaling β-catenin cancer stem cells TNBC early breast cancer bevacizumab neoadjuvant chemotherapy ALDH1 solid cancer chemo-resistance HDAC inhibitors head and neck squamous cell carcinoma SRC dasatinib saracatinib EC-8042 Ovarian cancer Wnt signaling tumor progression therapy resistance exosomes oral cancer risk oral epithelial dysplasia SOX2 immunohistochemistry oral squamous cell carcinoma genome-wide transcriptome lung cancer ATAC-seq RNA-seq CSCs NSCLC B4GALT1 LUAD breast cancer lipid metabolism therapeutic resistance bowel cancer organoid tumoroid colorectal colon stem cell chemotherapy resistance ovarian cancer cancer stem cell genetic heterogeneity SNP array L1CAM chemoresistance epithelial-mesenchymal transition cancer therapy cell adhesion molecule thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Cadherin 11 WNT signaling β-catenin cancer stem cells TNBC early breast cancer bevacizumab neoadjuvant chemotherapy ALDH1 solid cancer chemo-resistance HDAC inhibitors head and neck squamous cell carcinoma SRC dasatinib saracatinib EC-8042 Ovarian cancer Wnt signaling tumor progression therapy resistance exosomes oral cancer risk oral epithelial dysplasia SOX2 immunohistochemistry oral squamous cell carcinoma genome-wide transcriptome lung cancer ATAC-seq RNA-seq CSCs NSCLC B4GALT1 LUAD breast cancer lipid metabolism therapeutic resistance bowel cancer organoid tumoroid colorectal colon stem cell chemotherapy resistance ovarian cancer cancer stem cell genetic heterogeneity SNP array L1CAM chemoresistance epithelial-mesenchymal transition cancer therapy cell adhesion molecule thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20210501_9783039434060_1074 |