Bacteriophages
There is talk of an upcoming antibiotic armageddon, with untreatable post-operative infections, and similarly untreatable complications after chemotherapy. Indeed, the now famous “O’Neill Report” (https://amr-review.org/) suggests that, by 2050, more people might die from antibiotic-resistant bacter...
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| Format: | Online |
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| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online pristup: | ONIX_20210501_9783039434046_1079 |
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| collection | Directory of Open Access Books |
| description | There is talk of an upcoming antibiotic armageddon, with untreatable post-operative infections, and similarly untreatable complications after chemotherapy. Indeed, the now famous “O’Neill Report” (https://amr-review.org/) suggests that, by 2050, more people might die from antibiotic-resistant bacterial infections than from cancer. While we are still learning all the subtle drivers of antibiotic resistance, it seems increasingly clear that we need to take a “one health” approach, curtailing the use of antibiotics in both human and veterinary medicine. However, there are no new classes of antibiotics on our horizon. Maybe something that has been around “forever” can come to our rescue—bacteriophages! Nevertheless, it is also necessary to do things differently, and use these new antimicrobials appropriately. Therefore, an in-depth study of bacteriophage biology and case-by-case applications might be required. Whilst by no means comprehensive, this book does cover some of the many topics related to bacteriophages as antimicrobials, including their use in human therapy and aquaculture. It also explores the potential use of phage endolysins as substitutes of antibiotics in two sectors where there is an urgent need—human therapy and the agro-food industry. Last but not least, there is an excellent perspective article on phage therapy implementation. |
| format | Online |
| id | doab-20.500.12854ir-69333 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-693332024-03-31T13:09:35Z Bacteriophages Suárez, Pilar García Fernández, Lucía bacteriophages dairy industry pathogens lactic acid bacteria fermentation failure biofilms antimicrobial resistance antimicrobials lysins horizontal gene transfer, transduction biofilm phage therapy resistance bacteriophage models agent based mass action bacterial phage resistance regression modeling MRSA Clostridium difficile Clostridium difficile infection microbiome in vitro fermentation model marine vibrios biological control aquaculture interactions vibriosis Aeromonas hydrophila Motile Aeromonas Septicemia MAS multiple-antibiotic-resistance striped catfish (Pangasianodon hypophthalmus) endolysin antibiotics one health protein engineering Aeromonas salmonicida furunculosis phage-resistant mutants proteins infrared spectroscopy lysin lytic enzyme peptidoglycan hydrolase antimicrobial antibacterial antibiotic resistance bacteriophage therapy Nagoya Protocol CRISPR CAS phage isolation phage resistance Staphylococcus Kayvirus Vibrio anguillarum fish larvae challenge trials phage display enzybiotics Bacteriophages diabetic foot ulcer osteomyelitis Staphylococcus aureus Antibiotic-resistant bacteria lysogenic conversion prophage induction read recruitment shiga toxin American Foulbrood phage Paenibacillus larvae Brevibacillus laterosporus treatment safety bystander phage therapy Mycobacterium smegmatis mycobacteriophages directed evolution PlyC CHAP protein net charge CBD-independent FoldX STEC-specific bacteriophage whole genome sequencing STEC O145 strains antimicrobial agent Pseudomonas aeruginosa dual-species antibiotic synergy simultaneous sequential microbiome therapy evolution thema EDItEUR::M Medicine and Nursing There is talk of an upcoming antibiotic armageddon, with untreatable post-operative infections, and similarly untreatable complications after chemotherapy. Indeed, the now famous “O’Neill Report” (https://amr-review.org/) suggests that, by 2050, more people might die from antibiotic-resistant bacterial infections than from cancer. While we are still learning all the subtle drivers of antibiotic resistance, it seems increasingly clear that we need to take a “one health” approach, curtailing the use of antibiotics in both human and veterinary medicine. However, there are no new classes of antibiotics on our horizon. Maybe something that has been around “forever” can come to our rescue—bacteriophages! Nevertheless, it is also necessary to do things differently, and use these new antimicrobials appropriately. Therefore, an in-depth study of bacteriophage biology and case-by-case applications might be required. Whilst by no means comprehensive, this book does cover some of the many topics related to bacteriophages as antimicrobials, including their use in human therapy and aquaculture. It also explores the potential use of phage endolysins as substitutes of antibiotics in two sectors where there is an urgent need—human therapy and the agro-food industry. Last but not least, there is an excellent perspective article on phage therapy implementation. 2021-05-01T15:46:56Z 2021-05-01T15:46:56Z 2020 book ONIX_20210501_9783039434046_1079 9783039434046 9783039434053 https://directory.doabooks.org/handle/20.500.12854/69333 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3125 https://mdpi.com/books/pdfview/book/3125 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-405-3 10.3390/books978-3-03943-405-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039434046 9783039434053 390 Basel, Switzerland open access |
| spellingShingle | bacteriophages dairy industry pathogens lactic acid bacteria fermentation failure biofilms antimicrobial resistance antimicrobials lysins horizontal gene transfer, transduction biofilm phage therapy resistance bacteriophage models agent based mass action bacterial phage resistance regression modeling MRSA Clostridium difficile Clostridium difficile infection microbiome in vitro fermentation model marine vibrios biological control aquaculture interactions vibriosis Aeromonas hydrophila Motile Aeromonas Septicemia MAS multiple-antibiotic-resistance striped catfish (Pangasianodon hypophthalmus) endolysin antibiotics one health protein engineering Aeromonas salmonicida furunculosis phage-resistant mutants proteins infrared spectroscopy lysin lytic enzyme peptidoglycan hydrolase antimicrobial antibacterial antibiotic resistance bacteriophage therapy Nagoya Protocol CRISPR CAS phage isolation phage resistance Staphylococcus Kayvirus Vibrio anguillarum fish larvae challenge trials phage display enzybiotics Bacteriophages diabetic foot ulcer osteomyelitis Staphylococcus aureus Antibiotic-resistant bacteria lysogenic conversion prophage induction read recruitment shiga toxin American Foulbrood phage Paenibacillus larvae Brevibacillus laterosporus treatment safety bystander phage therapy Mycobacterium smegmatis mycobacteriophages directed evolution PlyC CHAP protein net charge CBD-independent FoldX STEC-specific bacteriophage whole genome sequencing STEC O145 strains antimicrobial agent Pseudomonas aeruginosa dual-species antibiotic synergy simultaneous sequential microbiome therapy evolution thema EDItEUR::M Medicine and Nursing Bacteriophages |
| title | Bacteriophages |
| title_full | Bacteriophages |
| title_fullStr | Bacteriophages |
| title_full_unstemmed | Bacteriophages |
| title_short | Bacteriophages |
| title_sort | bacteriophages |
| topic | bacteriophages dairy industry pathogens lactic acid bacteria fermentation failure biofilms antimicrobial resistance antimicrobials lysins horizontal gene transfer, transduction biofilm phage therapy resistance bacteriophage models agent based mass action bacterial phage resistance regression modeling MRSA Clostridium difficile Clostridium difficile infection microbiome in vitro fermentation model marine vibrios biological control aquaculture interactions vibriosis Aeromonas hydrophila Motile Aeromonas Septicemia MAS multiple-antibiotic-resistance striped catfish (Pangasianodon hypophthalmus) endolysin antibiotics one health protein engineering Aeromonas salmonicida furunculosis phage-resistant mutants proteins infrared spectroscopy lysin lytic enzyme peptidoglycan hydrolase antimicrobial antibacterial antibiotic resistance bacteriophage therapy Nagoya Protocol CRISPR CAS phage isolation phage resistance Staphylococcus Kayvirus Vibrio anguillarum fish larvae challenge trials phage display enzybiotics Bacteriophages diabetic foot ulcer osteomyelitis Staphylococcus aureus Antibiotic-resistant bacteria lysogenic conversion prophage induction read recruitment shiga toxin American Foulbrood phage Paenibacillus larvae Brevibacillus laterosporus treatment safety bystander phage therapy Mycobacterium smegmatis mycobacteriophages directed evolution PlyC CHAP protein net charge CBD-independent FoldX STEC-specific bacteriophage whole genome sequencing STEC O145 strains antimicrobial agent Pseudomonas aeruginosa dual-species antibiotic synergy simultaneous sequential microbiome therapy evolution thema EDItEUR::M Medicine and Nursing |
| topic_facet | bacteriophages dairy industry pathogens lactic acid bacteria fermentation failure biofilms antimicrobial resistance antimicrobials lysins horizontal gene transfer, transduction biofilm phage therapy resistance bacteriophage models agent based mass action bacterial phage resistance regression modeling MRSA Clostridium difficile Clostridium difficile infection microbiome in vitro fermentation model marine vibrios biological control aquaculture interactions vibriosis Aeromonas hydrophila Motile Aeromonas Septicemia MAS multiple-antibiotic-resistance striped catfish (Pangasianodon hypophthalmus) endolysin antibiotics one health protein engineering Aeromonas salmonicida furunculosis phage-resistant mutants proteins infrared spectroscopy lysin lytic enzyme peptidoglycan hydrolase antimicrobial antibacterial antibiotic resistance bacteriophage therapy Nagoya Protocol CRISPR CAS phage isolation phage resistance Staphylococcus Kayvirus Vibrio anguillarum fish larvae challenge trials phage display enzybiotics Bacteriophages diabetic foot ulcer osteomyelitis Staphylococcus aureus Antibiotic-resistant bacteria lysogenic conversion prophage induction read recruitment shiga toxin American Foulbrood phage Paenibacillus larvae Brevibacillus laterosporus treatment safety bystander phage therapy Mycobacterium smegmatis mycobacteriophages directed evolution PlyC CHAP protein net charge CBD-independent FoldX STEC-specific bacteriophage whole genome sequencing STEC O145 strains antimicrobial agent Pseudomonas aeruginosa dual-species antibiotic synergy simultaneous sequential microbiome therapy evolution thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039434046_1079 |