Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations
Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they...
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| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Online Access: | ONIX_20220111_9783036505626_212 |
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| description | Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field. |
| format | Online |
| id | doab-20.500.12854ir-76476 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-764762024-03-30T23:23:04Z Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations Ciarimboli, Giuliano transporters endogenous metabolism functional subgroups SLC22 remote sensing and signaling drug transporters gut microbiome chronic kidney disease solute carrier 22 (SLC22) Remote Sensing and Signaling Theory interorgan communication organic anion transporter organic cation transporter SLC22A15 SLC22A16 SLC22A18 kidney Malpighian tubule TCGA human pathology atlas gene ontology organic cations transport kidneys regulation Nuclear receptor renal excretion bile acids organic cation transporters drug disposition genetic polymorphisms drug-induced kidney injury nephrotoxicity RA Tofacitinib Baricitinib MATE1 solute carrier (SLC) family OCT1 SLC22A1 species differences drugs pesticides cisplatin nephrotoxicity PPAR-alpha organic transporters serotonin transporter plasma membrane monoamine transporter ketamine isoflurane serotonin clearance antidepressant-like activity chronoamperometry tail suspension test forced swim test hepatotoxicity solute carrier pulmonary drug delivery SLC22A1–5 lung epithelium drug uptake β2-agonists chronic lung diseases anticholinergics trospium OCT MATE drug excretion drug transport n/a thema EDItEUR::M Medicine and Nursing Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field. 2022-01-11T13:32:59Z 2022-01-11T13:32:59Z 2021 book ONIX_20220111_9783036505626_212 9783036505626 9783036505633 https://directory.doabooks.org/handle/20.500.12854/76476 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/3912 https://mdpi.com/books/pdfview/book/3912 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-0563-3 10.3390/books978-3-0365-0563-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036505626 9783036505633 248 Basel, Switzerland open access |
| spellingShingle | transporters endogenous metabolism functional subgroups SLC22 remote sensing and signaling drug transporters gut microbiome chronic kidney disease solute carrier 22 (SLC22) Remote Sensing and Signaling Theory interorgan communication organic anion transporter organic cation transporter SLC22A15 SLC22A16 SLC22A18 kidney Malpighian tubule TCGA human pathology atlas gene ontology organic cations transport kidneys regulation Nuclear receptor renal excretion bile acids organic cation transporters drug disposition genetic polymorphisms drug-induced kidney injury nephrotoxicity RA Tofacitinib Baricitinib MATE1 solute carrier (SLC) family OCT1 SLC22A1 species differences drugs pesticides cisplatin nephrotoxicity PPAR-alpha organic transporters serotonin transporter plasma membrane monoamine transporter ketamine isoflurane serotonin clearance antidepressant-like activity chronoamperometry tail suspension test forced swim test hepatotoxicity solute carrier pulmonary drug delivery SLC22A1–5 lung epithelium drug uptake β2-agonists chronic lung diseases anticholinergics trospium OCT MATE drug excretion drug transport n/a thema EDItEUR::M Medicine and Nursing Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
| title | Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
| title_full | Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
| title_fullStr | Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
| title_full_unstemmed | Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
| title_short | Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
| title_sort | physiology biochemistry and pharmacology of transporters for organic cations |
| topic | transporters endogenous metabolism functional subgroups SLC22 remote sensing and signaling drug transporters gut microbiome chronic kidney disease solute carrier 22 (SLC22) Remote Sensing and Signaling Theory interorgan communication organic anion transporter organic cation transporter SLC22A15 SLC22A16 SLC22A18 kidney Malpighian tubule TCGA human pathology atlas gene ontology organic cations transport kidneys regulation Nuclear receptor renal excretion bile acids organic cation transporters drug disposition genetic polymorphisms drug-induced kidney injury nephrotoxicity RA Tofacitinib Baricitinib MATE1 solute carrier (SLC) family OCT1 SLC22A1 species differences drugs pesticides cisplatin nephrotoxicity PPAR-alpha organic transporters serotonin transporter plasma membrane monoamine transporter ketamine isoflurane serotonin clearance antidepressant-like activity chronoamperometry tail suspension test forced swim test hepatotoxicity solute carrier pulmonary drug delivery SLC22A1–5 lung epithelium drug uptake β2-agonists chronic lung diseases anticholinergics trospium OCT MATE drug excretion drug transport n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | transporters endogenous metabolism functional subgroups SLC22 remote sensing and signaling drug transporters gut microbiome chronic kidney disease solute carrier 22 (SLC22) Remote Sensing and Signaling Theory interorgan communication organic anion transporter organic cation transporter SLC22A15 SLC22A16 SLC22A18 kidney Malpighian tubule TCGA human pathology atlas gene ontology organic cations transport kidneys regulation Nuclear receptor renal excretion bile acids organic cation transporters drug disposition genetic polymorphisms drug-induced kidney injury nephrotoxicity RA Tofacitinib Baricitinib MATE1 solute carrier (SLC) family OCT1 SLC22A1 species differences drugs pesticides cisplatin nephrotoxicity PPAR-alpha organic transporters serotonin transporter plasma membrane monoamine transporter ketamine isoflurane serotonin clearance antidepressant-like activity chronoamperometry tail suspension test forced swim test hepatotoxicity solute carrier pulmonary drug delivery SLC22A1–5 lung epithelium drug uptake β2-agonists chronic lung diseases anticholinergics trospium OCT MATE drug excretion drug transport n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20220111_9783036505626_212 |