Dietary Polyphenols and Neuroprotection
As editors of this book our aim was to collect new data from experienced authors in order to further advance the knowledge on the protective effects of polyphenols’ intake, e.g., when included in the human diet, to modulate cellular functions and pathways associated with neurodegenerative diseases.F...
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| フォーマット: | Online |
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| 言語: | 英語 |
| 出版事項: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| 主題: | |
| オンライン･アクセス: | ONIX_20220224_9783036528823_85 |
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| _version_ | 1869520457803235328 |
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| collection | Directory of Open Access Books |
| description | As editors of this book our aim was to collect new data from experienced authors in order to further advance the knowledge on the protective effects of polyphenols’ intake, e.g., when included in the human diet, to modulate cellular functions and pathways associated with neurodegenerative diseases.Fruits and vegetables are the richest source of polyphenols in the regular human diet. Most of these molecules possess high antioxidant capacity, as well as several other important activities that can affect human health, among which anti-inflammatory properties and the potential ability to modulate different cell-signalling pathways seem to be the most important. Neurodegenerative diseases are among the main causes of death worldwide and, in most of them like Alzheimer’s or Parkinson’s, neurodegeneration occurs long before the onset of first symptoms, where a large population of brain neurons are already lost. Besides neurons, glial cells like astrocytes and microglia, are involved in oxidative and neuroinflammatory pathological pathways, making them interesting targets for neuroprotective strategies. Polyphenols are promising candidates for those strategies, either as prophylactic substances or as therapeutic molecules.In this book, several research papers and two reviews explore the chemical properties of naturally occurring polyphenols and some new possibilities for the therapeutical and/or prophylactic roles of these molecules on neurodegeneration and neurodegenerative diseases. |
| format | Online |
| id | doab-20.500.12854ir-78787 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-787872024-03-31T13:08:32Z Dietary Polyphenols and Neuroprotection Silva, Rui F. M. Pogačnik, Lea oxidative stress ROS neurodegenerative diseases red grape polyphenol extract white grape seed polyphenol extract MecobalActive® Olews® Polygonum cuspidatum Reynoutria invasive species phenolic compounds flavan-3-ols stilbenes vitamin C size-exclusion chromatography DPPH test DPPH derivatization functional magnetic resonance imaging spectroscopy 7T polyphenols nutraceuticals antioxidants biosensors xanthine oxidase teas drugs ampelopsin A Vitis vinifera memory behavioral tests long-term potentiation CREB/BDNF signals EVOO polyphenols inflammation ALS FTD neurodegeneration resveratrol curcumin catechin EGCG epigallocatechin-3-gallate insulin-degrading enzyme aggregation amyloid-beta insulin flavones inhibition autoxidation n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences As editors of this book our aim was to collect new data from experienced authors in order to further advance the knowledge on the protective effects of polyphenols’ intake, e.g., when included in the human diet, to modulate cellular functions and pathways associated with neurodegenerative diseases.Fruits and vegetables are the richest source of polyphenols in the regular human diet. Most of these molecules possess high antioxidant capacity, as well as several other important activities that can affect human health, among which anti-inflammatory properties and the potential ability to modulate different cell-signalling pathways seem to be the most important. Neurodegenerative diseases are among the main causes of death worldwide and, in most of them like Alzheimer’s or Parkinson’s, neurodegeneration occurs long before the onset of first symptoms, where a large population of brain neurons are already lost. Besides neurons, glial cells like astrocytes and microglia, are involved in oxidative and neuroinflammatory pathological pathways, making them interesting targets for neuroprotective strategies. Polyphenols are promising candidates for those strategies, either as prophylactic substances or as therapeutic molecules.In this book, several research papers and two reviews explore the chemical properties of naturally occurring polyphenols and some new possibilities for the therapeutical and/or prophylactic roles of these molecules on neurodegeneration and neurodegenerative diseases. 2022-02-24T10:36:28Z 2022-02-24T10:36:28Z 2022 book ONIX_20220224_9783036528823_85 9783036528823 9783036528830 https://directory.doabooks.org/handle/20.500.12854/78787 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4881 https://mdpi.com/books/pdfview/book/4881 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-2882-3 10.3390/books978-3-0365-2882-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036528823 9783036528830 160 Basel open access |
| spellingShingle | oxidative stress ROS neurodegenerative diseases red grape polyphenol extract white grape seed polyphenol extract MecobalActive® Olews® Polygonum cuspidatum Reynoutria invasive species phenolic compounds flavan-3-ols stilbenes vitamin C size-exclusion chromatography DPPH test DPPH derivatization functional magnetic resonance imaging spectroscopy 7T polyphenols nutraceuticals antioxidants biosensors xanthine oxidase teas drugs ampelopsin A Vitis vinifera memory behavioral tests long-term potentiation CREB/BDNF signals EVOO polyphenols inflammation ALS FTD neurodegeneration resveratrol curcumin catechin EGCG epigallocatechin-3-gallate insulin-degrading enzyme aggregation amyloid-beta insulin flavones inhibition autoxidation n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Dietary Polyphenols and Neuroprotection |
| title | Dietary Polyphenols and Neuroprotection |
| title_full | Dietary Polyphenols and Neuroprotection |
| title_fullStr | Dietary Polyphenols and Neuroprotection |
| title_full_unstemmed | Dietary Polyphenols and Neuroprotection |
| title_short | Dietary Polyphenols and Neuroprotection |
| title_sort | dietary polyphenols and neuroprotection |
| topic | oxidative stress ROS neurodegenerative diseases red grape polyphenol extract white grape seed polyphenol extract MecobalActive® Olews® Polygonum cuspidatum Reynoutria invasive species phenolic compounds flavan-3-ols stilbenes vitamin C size-exclusion chromatography DPPH test DPPH derivatization functional magnetic resonance imaging spectroscopy 7T polyphenols nutraceuticals antioxidants biosensors xanthine oxidase teas drugs ampelopsin A Vitis vinifera memory behavioral tests long-term potentiation CREB/BDNF signals EVOO polyphenols inflammation ALS FTD neurodegeneration resveratrol curcumin catechin EGCG epigallocatechin-3-gallate insulin-degrading enzyme aggregation amyloid-beta insulin flavones inhibition autoxidation n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | oxidative stress ROS neurodegenerative diseases red grape polyphenol extract white grape seed polyphenol extract MecobalActive® Olews® Polygonum cuspidatum Reynoutria invasive species phenolic compounds flavan-3-ols stilbenes vitamin C size-exclusion chromatography DPPH test DPPH derivatization functional magnetic resonance imaging spectroscopy 7T polyphenols nutraceuticals antioxidants biosensors xanthine oxidase teas drugs ampelopsin A Vitis vinifera memory behavioral tests long-term potentiation CREB/BDNF signals EVOO polyphenols inflammation ALS FTD neurodegeneration resveratrol curcumin catechin EGCG epigallocatechin-3-gallate insulin-degrading enzyme aggregation amyloid-beta insulin flavones inhibition autoxidation n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20220224_9783036528823_85 |