A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research
During the last 60 years the relevance of cannabis (Cannabis sativa or Cannabis indica) ingredients, like the psychoactive Δ9-tetrahydrocannabinol (THC), cannabidiol, 120+ additional cannabinoids and 440+ non-cannabinoid compounds, for human health and disease has become apparent. Approximately 30 y...
محفوظ في:
| التنسيق: | Online |
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| اللغة: | الإنجليزية |
| منشور في: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | ONIX_20220506_9783036530062_96 |
| الوسوم: |
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
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| _version_ | 1869514669588217856 |
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| collection | Directory of Open Access Books |
| description | During the last 60 years the relevance of cannabis (Cannabis sativa or Cannabis indica) ingredients, like the psychoactive Δ9-tetrahydrocannabinol (THC), cannabidiol, 120+ additional cannabinoids and 440+ non-cannabinoid compounds, for human health and disease has become apparent. Approximately 30 years after the elucidation of THC structure the molecular reasons for the biological activity of these plant extracts were made clearer by the discovery of endocannabinoids, that are endogenous lipids able to bind to the same receptors activated by THC. Besides endocannabinoids, that include several N-acylethanolamines and acylesters, a complex array of receptors, metabolic enzymes, transporters (transmembrane, intracellular and extracellular carriers) were also discovered, and altogether they form a so-called “endocannabinoid system” that has been shown to finely tune the manifold biological activities of these lipid signals. Both plant-derived cannabinoids and endocannabinoids were first discovered by the group led by Prof. Dr. Raphael Mechoulam, who has just celebrated his 90th birthday and clearly stood out as a giant of modern science. The many implications of his seminal work for chemistry, biochemistry, biology, pharmacology and medicine are described in this special issue by the scientists who reached during the last 20 years the highest recognition in the field of (endo)cannabinoid research, receiving the Mechoulam Award for their major contributions. I thank them for having accepted my invitation to be part of this honorary issue of Molecules, and Raphi for continuing to illuminate our field with his always inspiring investigations and new ideas. |
| format | Online |
| id | doab-20.500.12854ir-81030 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-810302024-03-28T03:31:10Z A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research Maccarrone, Mauro cannabinoid MRI-1867 hybrid ligand CB1 receptor antagonist iNOS inhibitor rimonabant intracerebroventricular administration alcohol craving two-bottle paradigm drinking in the dark N-acyltransferase anandamide endocannabinoid phospholipase A2 cannabichromene cannabidiolic acid cannabidivarin cannabidivarinic acid phytocannabinoids tetrahydrocannabivarin 4′-fluoro-cannabidiol cannabinoid tetrad elevated plus maze catalepsy marble bury HUF-101 equilibrative nucleoside transporter CB1 biased signaling functional selectivity G-protein β-arrestin cannabigerol anti-inflammatory obesity cannabinoid receptor 2 (CB2R) microglia inflammaging memory lipofuscin aminoalkylindole allodynia antinociception cannabinoid receptor CP55940 JWH-018 K2 pravadoline spice WIN55212-2 type 1 cannabinoid receptor CB1 cholesterol hippocampus frontal cortex synaptosomes rescue model anti-CB1 antibody cannabinoids GPR55 receptors VCE-006.1 chromenopyrazole Parkinson’s disease 6-hydroxydopamine lipopolysaccharide amyotrophic lateral sclerosis mSOD1 mice TDP-43 transgenic mice PPARs gut microbiome intestine ghrelin LEAP2 n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry During the last 60 years the relevance of cannabis (Cannabis sativa or Cannabis indica) ingredients, like the psychoactive Δ9-tetrahydrocannabinol (THC), cannabidiol, 120+ additional cannabinoids and 440+ non-cannabinoid compounds, for human health and disease has become apparent. Approximately 30 years after the elucidation of THC structure the molecular reasons for the biological activity of these plant extracts were made clearer by the discovery of endocannabinoids, that are endogenous lipids able to bind to the same receptors activated by THC. Besides endocannabinoids, that include several N-acylethanolamines and acylesters, a complex array of receptors, metabolic enzymes, transporters (transmembrane, intracellular and extracellular carriers) were also discovered, and altogether they form a so-called “endocannabinoid system” that has been shown to finely tune the manifold biological activities of these lipid signals. Both plant-derived cannabinoids and endocannabinoids were first discovered by the group led by Prof. Dr. Raphael Mechoulam, who has just celebrated his 90th birthday and clearly stood out as a giant of modern science. The many implications of his seminal work for chemistry, biochemistry, biology, pharmacology and medicine are described in this special issue by the scientists who reached during the last 20 years the highest recognition in the field of (endo)cannabinoid research, receiving the Mechoulam Award for their major contributions. I thank them for having accepted my invitation to be part of this honorary issue of Molecules, and Raphi for continuing to illuminate our field with his always inspiring investigations and new ideas. 2022-05-06T11:22:42Z 2022-05-06T11:22:42Z 2022 book ONIX_20220506_9783036530062_96 9783036530062 9783036530079 https://directory.doabooks.org/handle/20.500.12854/81030 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/5372 https://mdpi.com/books/pdfview/book/5372 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3007-9 10.3390/books978-3-0365-3007-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036530062 9783036530079 236 Basel open access |
| spellingShingle | cannabinoid MRI-1867 hybrid ligand CB1 receptor antagonist iNOS inhibitor rimonabant intracerebroventricular administration alcohol craving two-bottle paradigm drinking in the dark N-acyltransferase anandamide endocannabinoid phospholipase A2 cannabichromene cannabidiolic acid cannabidivarin cannabidivarinic acid phytocannabinoids tetrahydrocannabivarin 4′-fluoro-cannabidiol cannabinoid tetrad elevated plus maze catalepsy marble bury HUF-101 equilibrative nucleoside transporter CB1 biased signaling functional selectivity G-protein β-arrestin cannabigerol anti-inflammatory obesity cannabinoid receptor 2 (CB2R) microglia inflammaging memory lipofuscin aminoalkylindole allodynia antinociception cannabinoid receptor CP55940 JWH-018 K2 pravadoline spice WIN55212-2 type 1 cannabinoid receptor CB1 cholesterol hippocampus frontal cortex synaptosomes rescue model anti-CB1 antibody cannabinoids GPR55 receptors VCE-006.1 chromenopyrazole Parkinson’s disease 6-hydroxydopamine lipopolysaccharide amyotrophic lateral sclerosis mSOD1 mice TDP-43 transgenic mice PPARs gut microbiome intestine ghrelin LEAP2 n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
| title | A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
| title_full | A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
| title_fullStr | A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
| title_full_unstemmed | A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
| title_short | A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
| title_sort | themed issue in honor of professor raphael mechoulam the father of cannabinoid and endocannabinoid research |
| topic | cannabinoid MRI-1867 hybrid ligand CB1 receptor antagonist iNOS inhibitor rimonabant intracerebroventricular administration alcohol craving two-bottle paradigm drinking in the dark N-acyltransferase anandamide endocannabinoid phospholipase A2 cannabichromene cannabidiolic acid cannabidivarin cannabidivarinic acid phytocannabinoids tetrahydrocannabivarin 4′-fluoro-cannabidiol cannabinoid tetrad elevated plus maze catalepsy marble bury HUF-101 equilibrative nucleoside transporter CB1 biased signaling functional selectivity G-protein β-arrestin cannabigerol anti-inflammatory obesity cannabinoid receptor 2 (CB2R) microglia inflammaging memory lipofuscin aminoalkylindole allodynia antinociception cannabinoid receptor CP55940 JWH-018 K2 pravadoline spice WIN55212-2 type 1 cannabinoid receptor CB1 cholesterol hippocampus frontal cortex synaptosomes rescue model anti-CB1 antibody cannabinoids GPR55 receptors VCE-006.1 chromenopyrazole Parkinson’s disease 6-hydroxydopamine lipopolysaccharide amyotrophic lateral sclerosis mSOD1 mice TDP-43 transgenic mice PPARs gut microbiome intestine ghrelin LEAP2 n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | cannabinoid MRI-1867 hybrid ligand CB1 receptor antagonist iNOS inhibitor rimonabant intracerebroventricular administration alcohol craving two-bottle paradigm drinking in the dark N-acyltransferase anandamide endocannabinoid phospholipase A2 cannabichromene cannabidiolic acid cannabidivarin cannabidivarinic acid phytocannabinoids tetrahydrocannabivarin 4′-fluoro-cannabidiol cannabinoid tetrad elevated plus maze catalepsy marble bury HUF-101 equilibrative nucleoside transporter CB1 biased signaling functional selectivity G-protein β-arrestin cannabigerol anti-inflammatory obesity cannabinoid receptor 2 (CB2R) microglia inflammaging memory lipofuscin aminoalkylindole allodynia antinociception cannabinoid receptor CP55940 JWH-018 K2 pravadoline spice WIN55212-2 type 1 cannabinoid receptor CB1 cholesterol hippocampus frontal cortex synaptosomes rescue model anti-CB1 antibody cannabinoids GPR55 receptors VCE-006.1 chromenopyrazole Parkinson’s disease 6-hydroxydopamine lipopolysaccharide amyotrophic lateral sclerosis mSOD1 mice TDP-43 transgenic mice PPARs gut microbiome intestine ghrelin LEAP2 n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | ONIX_20220506_9783036530062_96 |