صورة الغلاف

Targeting Wnt Signaling in Cancer: Opportunities Abound If We Can Avoid the Sword of Damocles

Dysregulation of Wnt signaling is known to be associated with various cancers. As such, identification of novel Wnt pathway targets in cancer and better characterization of already-known targets present exciting, emerging opportunities for cancer treatment. In this Special Issue, we feature papers w...

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محفوظ في:
التنسيق: Online
اللغة:الإنجليزية
منشور في: MDPI - Multidisciplinary Digital Publishing Institute 2022
الموضوعات:
Wnt signaling
synovial sarcoma
TNIK
NCB-0846
MYC
hepatitis B virus
HBV
cancer
liver cancer
β-catenin
TCF/LEF
pancreatic cancer
pancreatic stellate cells
CBP
p300
pancreatitis
fibrosis
just-right signaling
APC
colorectal cancer
RNA-binding proteins
Musashi
drug discovery
Notch signaling
cancer therapy
fungi secondary metabolite derivative
microenvironment
Wnt
AML
drug target
signaling
colorectal
porcupine
R-spondin
serrated
immunotherapy
wnt
vitamin D
colon cancer
L1
Wnt target genes
cell adhesion
NF-κB
invasion and metastasis
cancer stem cells
EMT
Lgr5
Wnt/beta-catenin signaling
angiogenesis
anti-angiogenic therapy
gastrointestinal cancers
therapeutic targeting of Wnt signaling
β-catenin paradox
molecular targeting
urothelial cancer
immune checkpoint inhibitor
immunotherapy resistance
IBD
colitis
β-catenin mutations
tumor metabolism
tumor immunology
molecular therapeutics
precision medicine
astrocytic brain tumors
DKKs
GSK3β
thema EDItEUR::M Medicine and Nursing
thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
الوصول للمادة أونلاين:ONIX_20220506_9783036535173_279
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الملخص:Dysregulation of Wnt signaling is known to be associated with various cancers. As such, identification of novel Wnt pathway targets in cancer and better characterization of already-known targets present exciting, emerging opportunities for cancer treatment. In this Special Issue, we feature papers which discuss the role of Wnt signaling and associated targets in cancer metabolism, tumor immune response, and tumor microenvironment. Papers discussing a range of Wnt-mediated cancers, including those of the colon, liver, pancreas, synovium, bladder, etc., are included.

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