Oxidative Stress and Inflammation
In the biochemical reactions that take place within all living beings, species called free radicals are generated. Denham Harman, in his study on the origin and evolution of life (Harman, 2001), proposes that these species are amongst the causes of the origin of life on our planet. Oxygen is a molec...
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| description | In the biochemical reactions that take place within all living beings, species called free radicals are generated. Denham Harman, in his study on the origin and evolution of life (Harman, 2001), proposes that these species are amongst the causes of the origin of life on our planet. Oxygen is a molecule that provides the primary source of energy in aerobic organisms and therefore is key to the development and evolution of life. On the one hand, it gives rise to life; on the other, due to its ability to form different free radicals, it is capable of damaging essential structures for development. To combat these radicals, our biological systems have developed antioxidant defenses. However, when the balance between free radicals and antioxidant defenses is broken in favor of the former, a phenomenon called oxidative stress occurs, which ends up damaging molecules such as DNA, proteins, carbohydrates, and lipids (Sies, 1983) (Halliwell and Gutteridge, 1985). This phenomenon is implicated both in the development of diseases and in their progression. In addition, inflammation phenomena are also involved in most pathologies, which, although they are essential for tissue repair and immunity, turn against our bodies when they become excessively active. For these reasons, in this special edition we showcase an extensive knowledge of the effects of oxidative stress and inflammation both in diseases such as aging, or for its role in health. |
| format | Online |
| id | doab-20.500.12854ir-94586 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-945862024-03-31T13:09:05Z Oxidative Stress and Inflammation Gambini, Juan diospyrin lipopolysaccharide anti-inflammation macrophages nitric oxide cytokine calcium CHOP Fas p38 MAPK Astragalus mongholicus Bunge danazol telomere telomerase aging diabetic kidney disease oxidative stress redox imbalance hyperimmunized milk exercise inflammation intestinal permeability acute respiratory distress syndrome antiplatelet aspirin therapy gender membrane erythrocyte hydroperoxides biomarker DPPP DPH TMA cardiovascular disease data analysis precision–recall Mediterranean diet Oriental diet nutrition polyphenols microbiota health n-3 PUFAs endogenous antioxidants anti-inflammatory response cardiovascular diseases dry eye syndrome corneal damage tear lipidome 5-lipoxigenase leukotriene B4 prostaglandins dimethyl sulfoxide zileuton air pollution soot particulate matter lung inflammation functional groups microglia porcine liver decomposition product lysophospholipids mild cognitive impairment dementia neuroinflammation cytokines oxygen reactive species caloric restriction oxidative balance adiponectin plasma white adipose tissue experimental model anti-inflammatory diets inflammatory response chronic inflammation low grade chronic inflammation inflammatory models cyclophosphamide doxorubicin docetaxel paclitaxel n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine In the biochemical reactions that take place within all living beings, species called free radicals are generated. Denham Harman, in his study on the origin and evolution of life (Harman, 2001), proposes that these species are amongst the causes of the origin of life on our planet. Oxygen is a molecule that provides the primary source of energy in aerobic organisms and therefore is key to the development and evolution of life. On the one hand, it gives rise to life; on the other, due to its ability to form different free radicals, it is capable of damaging essential structures for development. To combat these radicals, our biological systems have developed antioxidant defenses. However, when the balance between free radicals and antioxidant defenses is broken in favor of the former, a phenomenon called oxidative stress occurs, which ends up damaging molecules such as DNA, proteins, carbohydrates, and lipids (Sies, 1983) (Halliwell and Gutteridge, 1985). This phenomenon is implicated both in the development of diseases and in their progression. In addition, inflammation phenomena are also involved in most pathologies, which, although they are essential for tissue repair and immunity, turn against our bodies when they become excessively active. For these reasons, in this special edition we showcase an extensive knowledge of the effects of oxidative stress and inflammation both in diseases such as aging, or for its role in health. 2022-12-06T16:13:05Z 2022-12-06T16:13:05Z 2022 book ONIX_20221206_9783036560236_109 9783036560236 9783036560243 https://directory.doabooks.org/handle/20.500.12854/94586 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6422 https://mdpi.com/books/pdfview/book/6422 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6024-3 10.3390/books978-3-0365-6024-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036560236 9783036560243 234 Basel open access |
| spellingShingle | diospyrin lipopolysaccharide anti-inflammation macrophages nitric oxide cytokine calcium CHOP Fas p38 MAPK Astragalus mongholicus Bunge danazol telomere telomerase aging diabetic kidney disease oxidative stress redox imbalance hyperimmunized milk exercise inflammation intestinal permeability acute respiratory distress syndrome antiplatelet aspirin therapy gender membrane erythrocyte hydroperoxides biomarker DPPP DPH TMA cardiovascular disease data analysis precision–recall Mediterranean diet Oriental diet nutrition polyphenols microbiota health n-3 PUFAs endogenous antioxidants anti-inflammatory response cardiovascular diseases dry eye syndrome corneal damage tear lipidome 5-lipoxigenase leukotriene B4 prostaglandins dimethyl sulfoxide zileuton air pollution soot particulate matter lung inflammation functional groups microglia porcine liver decomposition product lysophospholipids mild cognitive impairment dementia neuroinflammation cytokines oxygen reactive species caloric restriction oxidative balance adiponectin plasma white adipose tissue experimental model anti-inflammatory diets inflammatory response chronic inflammation low grade chronic inflammation inflammatory models cyclophosphamide doxorubicin docetaxel paclitaxel n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine Oxidative Stress and Inflammation |
| title | Oxidative Stress and Inflammation |
| title_full | Oxidative Stress and Inflammation |
| title_fullStr | Oxidative Stress and Inflammation |
| title_full_unstemmed | Oxidative Stress and Inflammation |
| title_short | Oxidative Stress and Inflammation |
| title_sort | oxidative stress and inflammation |
| topic | diospyrin lipopolysaccharide anti-inflammation macrophages nitric oxide cytokine calcium CHOP Fas p38 MAPK Astragalus mongholicus Bunge danazol telomere telomerase aging diabetic kidney disease oxidative stress redox imbalance hyperimmunized milk exercise inflammation intestinal permeability acute respiratory distress syndrome antiplatelet aspirin therapy gender membrane erythrocyte hydroperoxides biomarker DPPP DPH TMA cardiovascular disease data analysis precision–recall Mediterranean diet Oriental diet nutrition polyphenols microbiota health n-3 PUFAs endogenous antioxidants anti-inflammatory response cardiovascular diseases dry eye syndrome corneal damage tear lipidome 5-lipoxigenase leukotriene B4 prostaglandins dimethyl sulfoxide zileuton air pollution soot particulate matter lung inflammation functional groups microglia porcine liver decomposition product lysophospholipids mild cognitive impairment dementia neuroinflammation cytokines oxygen reactive species caloric restriction oxidative balance adiponectin plasma white adipose tissue experimental model anti-inflammatory diets inflammatory response chronic inflammation low grade chronic inflammation inflammatory models cyclophosphamide doxorubicin docetaxel paclitaxel n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine |
| topic_facet | diospyrin lipopolysaccharide anti-inflammation macrophages nitric oxide cytokine calcium CHOP Fas p38 MAPK Astragalus mongholicus Bunge danazol telomere telomerase aging diabetic kidney disease oxidative stress redox imbalance hyperimmunized milk exercise inflammation intestinal permeability acute respiratory distress syndrome antiplatelet aspirin therapy gender membrane erythrocyte hydroperoxides biomarker DPPP DPH TMA cardiovascular disease data analysis precision–recall Mediterranean diet Oriental diet nutrition polyphenols microbiota health n-3 PUFAs endogenous antioxidants anti-inflammatory response cardiovascular diseases dry eye syndrome corneal damage tear lipidome 5-lipoxigenase leukotriene B4 prostaglandins dimethyl sulfoxide zileuton air pollution soot particulate matter lung inflammation functional groups microglia porcine liver decomposition product lysophospholipids mild cognitive impairment dementia neuroinflammation cytokines oxygen reactive species caloric restriction oxidative balance adiponectin plasma white adipose tissue experimental model anti-inflammatory diets inflammatory response chronic inflammation low grade chronic inflammation inflammatory models cyclophosphamide doxorubicin docetaxel paclitaxel n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine |
| url | ONIX_20221206_9783036560236_109 |