Omslagsbillede

Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer

This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors describe the use of established, time-honored exper...

Fuld beskrivelse

Saved in:
Format: Online
Sprog:engelsk
Udgivet: MDPI - Multidisciplinary Digital Publishing Institute 2023
Fag:
nucleic acid structures
nucleic acid conformation
biological structure database
DNA
RNA
validation standards
G-quadruplex
replication
thermodynamics
ligand
topology
quadruplex-duplex hybrids
minor groove binding drugs
stability
optical spectroscopy
nucleic acids
charge
electrostatic potential
ab initio methods
NMR spectroscopy
molecular dynamics
forcefield
AMBER
B-DNA
DNA-hairpin
perchlorates
brines
pressure
Mars
habitability
DNA minor groove binder
mixed base-pair DNA sequences
sequence selectivity
ligand–DNA complex thermodynamic
molecular curvature
heterocyclic diamidine
biosensor
calorimetry
DNA conjugate
metal ion
triple helix
silver ion
lanthanide
ATP sensor
aptamer
terpyridine
sequence edition
DNAzyme
molecular dynamics simulation (MD)
potential of mean force (PMF)
dsDNA–dsDNA interactions
flexibility
origins of life
DNA-protein networks
protocells
DNA sequence-dependent structure
DNA deformability
DNA sequence context
DNA curvature
DNA minicircles
hydrostatic pressure
volume
CD spectroscopy
G-quadruplexes
potassium
polymorphism
kinetics
folding
kinetic models
fitting
aurintricarboxylic acid (ATA)
salicylic acid polymers
methylene-salicylic acid
SARS-CoV-2
RNA-dependent RNA polymerase (RdRp)
yeast ribosomes
human serum albumin (HSA)
molecular recognition
biological function and viral disease
inhibitor binding
single-molecule biophysics
nucleic acid thermodynamics
statistical mechanics
fluctuation theorems
computational biophysics
n/a
drug discovery
drug-target interactions
thermodynamic binding signatures
isothermal titration calorimetry
lead optimization
fragment-based drug discovery
drug-like properties
enthalpic efficiency
group efficiency
lipophilic efficiency
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online adgang:ONIX_20230202_9783036560984_29
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
Summary:This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors describe the use of established, time-honored experimental and computational techniques as well as their more recently developed counterparts. Molecular insights that can be gained from the papers collected in this issue range from the fundamental to the applied with emphasis on biological functions and biomedical prospects of nucleic acids. The collection is not meant to be exhaustive, but to highlight recent advances from select laboratories worldwide. Nevertheless, it represents a useful guide for scientists who wish to familiarize themselves with biophysical topics in nucleic acid research. This Special Issue will be useful both for researchers who study fundamental aspects of nucleic acid structure, stability, and dynamics, as well as for those that are mainly interested in practical biological and biomedical applications of nucleic acids.

Lignende værker