Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer
This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors describe the use of established, time-honored exper...
সংরক্ষণ করুন:
| বিন্যাস: | Online |
|---|---|
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
|
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | ONIX_20230202_9783036560984_29 |
| ট্যাগগুলো: |
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
|
| _version_ | 1869517177163350016 |
|---|---|
| collection | Directory of Open Access Books |
| description | This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors describe the use of established, time-honored experimental and computational techniques as well as their more recently developed counterparts. Molecular insights that can be gained from the papers collected in this issue range from the fundamental to the applied with emphasis on biological functions and biomedical prospects of nucleic acids. The collection is not meant to be exhaustive, but to highlight recent advances from select laboratories worldwide. Nevertheless, it represents a useful guide for scientists who wish to familiarize themselves with biophysical topics in nucleic acid research. This Special Issue will be useful both for researchers who study fundamental aspects of nucleic acid structure, stability, and dynamics, as well as for those that are mainly interested in practical biological and biomedical applications of nucleic acids. |
| format | Online |
| id | doab-20.500.12854ir-96628 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-966282024-03-28T03:33:16Z Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer Chalikian, Tigran Völker, Jens nucleic acid structures nucleic acid conformation biological structure database DNA RNA validation standards G-quadruplex replication thermodynamics ligand topology quadruplex-duplex hybrids minor groove binding drugs stability optical spectroscopy nucleic acids charge electrostatic potential ab initio methods NMR spectroscopy molecular dynamics forcefield AMBER B-DNA DNA-hairpin perchlorates brines pressure Mars habitability DNA minor groove binder mixed base-pair DNA sequences sequence selectivity ligand–DNA complex thermodynamic molecular curvature heterocyclic diamidine biosensor calorimetry DNA conjugate metal ion triple helix silver ion lanthanide ATP sensor aptamer terpyridine sequence edition DNAzyme molecular dynamics simulation (MD) potential of mean force (PMF) dsDNA–dsDNA interactions flexibility origins of life DNA-protein networks protocells DNA sequence-dependent structure DNA deformability DNA sequence context DNA curvature DNA minicircles hydrostatic pressure volume CD spectroscopy G-quadruplexes potassium polymorphism kinetics folding kinetic models fitting aurintricarboxylic acid (ATA) salicylic acid polymers methylene-salicylic acid SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) yeast ribosomes human serum albumin (HSA) molecular recognition biological function and viral disease inhibitor binding single-molecule biophysics nucleic acid thermodynamics statistical mechanics fluctuation theorems computational biophysics n/a drug discovery drug-target interactions thermodynamic binding signatures isothermal titration calorimetry lead optimization fragment-based drug discovery drug-like properties enthalpic efficiency group efficiency lipophilic efficiency thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors describe the use of established, time-honored experimental and computational techniques as well as their more recently developed counterparts. Molecular insights that can be gained from the papers collected in this issue range from the fundamental to the applied with emphasis on biological functions and biomedical prospects of nucleic acids. The collection is not meant to be exhaustive, but to highlight recent advances from select laboratories worldwide. Nevertheless, it represents a useful guide for scientists who wish to familiarize themselves with biophysical topics in nucleic acid research. This Special Issue will be useful both for researchers who study fundamental aspects of nucleic acid structure, stability, and dynamics, as well as for those that are mainly interested in practical biological and biomedical applications of nucleic acids. 2023-02-02T16:26:46Z 2023-02-02T16:26:46Z 2023 book ONIX_20230202_9783036560984_29 9783036560984 9783036560977 https://directory.doabooks.org/handle/20.500.12854/96628 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6573 https://mdpi.com/books/pdfview/book/6573 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6097-7 10.3390/books978-3-0365-6097-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036560984 9783036560977 282 Basel open access |
| spellingShingle | nucleic acid structures nucleic acid conformation biological structure database DNA RNA validation standards G-quadruplex replication thermodynamics ligand topology quadruplex-duplex hybrids minor groove binding drugs stability optical spectroscopy nucleic acids charge electrostatic potential ab initio methods NMR spectroscopy molecular dynamics forcefield AMBER B-DNA DNA-hairpin perchlorates brines pressure Mars habitability DNA minor groove binder mixed base-pair DNA sequences sequence selectivity ligand–DNA complex thermodynamic molecular curvature heterocyclic diamidine biosensor calorimetry DNA conjugate metal ion triple helix silver ion lanthanide ATP sensor aptamer terpyridine sequence edition DNAzyme molecular dynamics simulation (MD) potential of mean force (PMF) dsDNA–dsDNA interactions flexibility origins of life DNA-protein networks protocells DNA sequence-dependent structure DNA deformability DNA sequence context DNA curvature DNA minicircles hydrostatic pressure volume CD spectroscopy G-quadruplexes potassium polymorphism kinetics folding kinetic models fitting aurintricarboxylic acid (ATA) salicylic acid polymers methylene-salicylic acid SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) yeast ribosomes human serum albumin (HSA) molecular recognition biological function and viral disease inhibitor binding single-molecule biophysics nucleic acid thermodynamics statistical mechanics fluctuation theorems computational biophysics n/a drug discovery drug-target interactions thermodynamic binding signatures isothermal titration calorimetry lead optimization fragment-based drug discovery drug-like properties enthalpic efficiency group efficiency lipophilic efficiency thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer |
| title | Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer |
| title_full | Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer |
| title_fullStr | Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer |
| title_full_unstemmed | Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer |
| title_short | Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer |
| title_sort | biophysics of nucleic acids celebrating the 75th birthday of professor kenneth j breslauer |
| topic | nucleic acid structures nucleic acid conformation biological structure database DNA RNA validation standards G-quadruplex replication thermodynamics ligand topology quadruplex-duplex hybrids minor groove binding drugs stability optical spectroscopy nucleic acids charge electrostatic potential ab initio methods NMR spectroscopy molecular dynamics forcefield AMBER B-DNA DNA-hairpin perchlorates brines pressure Mars habitability DNA minor groove binder mixed base-pair DNA sequences sequence selectivity ligand–DNA complex thermodynamic molecular curvature heterocyclic diamidine biosensor calorimetry DNA conjugate metal ion triple helix silver ion lanthanide ATP sensor aptamer terpyridine sequence edition DNAzyme molecular dynamics simulation (MD) potential of mean force (PMF) dsDNA–dsDNA interactions flexibility origins of life DNA-protein networks protocells DNA sequence-dependent structure DNA deformability DNA sequence context DNA curvature DNA minicircles hydrostatic pressure volume CD spectroscopy G-quadruplexes potassium polymorphism kinetics folding kinetic models fitting aurintricarboxylic acid (ATA) salicylic acid polymers methylene-salicylic acid SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) yeast ribosomes human serum albumin (HSA) molecular recognition biological function and viral disease inhibitor binding single-molecule biophysics nucleic acid thermodynamics statistical mechanics fluctuation theorems computational biophysics n/a drug discovery drug-target interactions thermodynamic binding signatures isothermal titration calorimetry lead optimization fragment-based drug discovery drug-like properties enthalpic efficiency group efficiency lipophilic efficiency thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | nucleic acid structures nucleic acid conformation biological structure database DNA RNA validation standards G-quadruplex replication thermodynamics ligand topology quadruplex-duplex hybrids minor groove binding drugs stability optical spectroscopy nucleic acids charge electrostatic potential ab initio methods NMR spectroscopy molecular dynamics forcefield AMBER B-DNA DNA-hairpin perchlorates brines pressure Mars habitability DNA minor groove binder mixed base-pair DNA sequences sequence selectivity ligand–DNA complex thermodynamic molecular curvature heterocyclic diamidine biosensor calorimetry DNA conjugate metal ion triple helix silver ion lanthanide ATP sensor aptamer terpyridine sequence edition DNAzyme molecular dynamics simulation (MD) potential of mean force (PMF) dsDNA–dsDNA interactions flexibility origins of life DNA-protein networks protocells DNA sequence-dependent structure DNA deformability DNA sequence context DNA curvature DNA minicircles hydrostatic pressure volume CD spectroscopy G-quadruplexes potassium polymorphism kinetics folding kinetic models fitting aurintricarboxylic acid (ATA) salicylic acid polymers methylene-salicylic acid SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) yeast ribosomes human serum albumin (HSA) molecular recognition biological function and viral disease inhibitor binding single-molecule biophysics nucleic acid thermodynamics statistical mechanics fluctuation theorems computational biophysics n/a drug discovery drug-target interactions thermodynamic binding signatures isothermal titration calorimetry lead optimization fragment-based drug discovery drug-like properties enthalpic efficiency group efficiency lipophilic efficiency thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230202_9783036560984_29 |