Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches
This reprint focuses on fundamental and applied research involving the combination of biomaterials and cancer cells to develop a three-dimensional (3D) tumor microenvironment in vitro, in which carcinogenesis mechanisms can be studied and therapies can be screened. Such models are becoming quite pop...
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| Formaat: | Online |
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| Taal: | Engels |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online toegang: | ONIX_20230405_9783036568423_161 |
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| collection | Directory of Open Access Books |
| description | This reprint focuses on fundamental and applied research involving the combination of biomaterials and cancer cells to develop a three-dimensional (3D) tumor microenvironment in vitro, in which carcinogenesis mechanisms can be studied and therapies can be screened. Such models are becoming quite popular within the bioengineering community; thus, many technologies are being tested to obtain the best scaffold for each tumor. In any case, only a tight interaction of bioengineers with cancer biologists and oncologists can make such 3D models progress, with them finally reaching a clinical relevance. On the other hand, the medical community is approaching simpler 3D in vitro models not provided with sufficient extracellular matrix biomimicry, such as spheroids and organoids, which may not be self-exhaustive; therefore, cancer researchers could benefit from closer contact with bioengineers. The aim of this reprint is to help generate shared knowledge and promote strong interdisciplinary collaboration with the ultimate goal of contributing to the acceleration of the discovery and validation of more precise therapies to fight cancer. |
| format | Online |
| id | doab-20.500.12854ir-98882 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-988822024-03-31T13:10:45Z Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches Danti, Serena Negrini, Nicola Contessi Franchi, Alessandro biomaterials tissue engineering 3D cell culture cancer cells bioprinting breast cancer metastasis bone 3D modeling tumor microenvironment extracellular matrix 3D printing 3D bioprinting bone cancer calcium phosphates bone model orthopedics EGFR trafficking degradation self-assembling peptides 3D culture pancreatic ductal adenocarcinoma PDAC drug resistance 3D tumor model 3D microfiber amoeboid cell migration brain cancer PTEN RHO ROCK durotaxis topotaxis pancreatic cancer tumour microenvironment (TME) treatment resistance radiotherapy radiation radioprotection hypoxia polyurethane scaffolds extracellular matrix (ECM) HIF-1a PANC-1 organoids tumour heterogeneity colorectal neoplasms clonal evolution longitudinal imaging neoplasm recurrence cell lineage self-renewal cell culture techniques 3D cancer models immunotherapies tumor escape mechanisms epithelial ovarian cancer 3D in vitro model chemotherapy Cisplatin spheroids hydrogels polymeric scaffolds A2780 SK-OV-3 fused deposition modeling cancer tissue engineering in vitro model mechanical properties mesenchymal stromal cell bone matrix personalized therapy scaffold primary cancer cells experimental models screening 3Rs tumour modelling polyhydroxyalkanoates (PHAs) colon cancer epithelial-mesenchymal transition (EMT) scaffolds 3D three-dimensional model ovarian cancer patient-derived personalised n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology This reprint focuses on fundamental and applied research involving the combination of biomaterials and cancer cells to develop a three-dimensional (3D) tumor microenvironment in vitro, in which carcinogenesis mechanisms can be studied and therapies can be screened. Such models are becoming quite popular within the bioengineering community; thus, many technologies are being tested to obtain the best scaffold for each tumor. In any case, only a tight interaction of bioengineers with cancer biologists and oncologists can make such 3D models progress, with them finally reaching a clinical relevance. On the other hand, the medical community is approaching simpler 3D in vitro models not provided with sufficient extracellular matrix biomimicry, such as spheroids and organoids, which may not be self-exhaustive; therefore, cancer researchers could benefit from closer contact with bioengineers. The aim of this reprint is to help generate shared knowledge and promote strong interdisciplinary collaboration with the ultimate goal of contributing to the acceleration of the discovery and validation of more precise therapies to fight cancer. 2023-04-05T12:56:59Z 2023-04-05T12:56:59Z 2023 book ONIX_20230405_9783036568423_161 9783036568423 9783036568430 https://directory.doabooks.org/handle/20.500.12854/98882 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/6935 https://mdpi.com/books/pdfview/book/6935 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6843-0 10.3390/books978-3-0365-6843-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036568423 9783036568430 312 Basel open access |
| spellingShingle | biomaterials tissue engineering 3D cell culture cancer cells bioprinting breast cancer metastasis bone 3D modeling tumor microenvironment extracellular matrix 3D printing 3D bioprinting bone cancer calcium phosphates bone model orthopedics EGFR trafficking degradation self-assembling peptides 3D culture pancreatic ductal adenocarcinoma PDAC drug resistance 3D tumor model 3D microfiber amoeboid cell migration brain cancer PTEN RHO ROCK durotaxis topotaxis pancreatic cancer tumour microenvironment (TME) treatment resistance radiotherapy radiation radioprotection hypoxia polyurethane scaffolds extracellular matrix (ECM) HIF-1a PANC-1 organoids tumour heterogeneity colorectal neoplasms clonal evolution longitudinal imaging neoplasm recurrence cell lineage self-renewal cell culture techniques 3D cancer models immunotherapies tumor escape mechanisms epithelial ovarian cancer 3D in vitro model chemotherapy Cisplatin spheroids hydrogels polymeric scaffolds A2780 SK-OV-3 fused deposition modeling cancer tissue engineering in vitro model mechanical properties mesenchymal stromal cell bone matrix personalized therapy scaffold primary cancer cells experimental models screening 3Rs tumour modelling polyhydroxyalkanoates (PHAs) colon cancer epithelial-mesenchymal transition (EMT) scaffolds 3D three-dimensional model ovarian cancer patient-derived personalised n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches |
| title | Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches |
| title_full | Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches |
| title_fullStr | Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches |
| title_full_unstemmed | Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches |
| title_short | Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches |
| title_sort | biomaterial assisted 3d in vitro tumor models from organoid towards cancer tissue engineering approaches |
| topic | biomaterials tissue engineering 3D cell culture cancer cells bioprinting breast cancer metastasis bone 3D modeling tumor microenvironment extracellular matrix 3D printing 3D bioprinting bone cancer calcium phosphates bone model orthopedics EGFR trafficking degradation self-assembling peptides 3D culture pancreatic ductal adenocarcinoma PDAC drug resistance 3D tumor model 3D microfiber amoeboid cell migration brain cancer PTEN RHO ROCK durotaxis topotaxis pancreatic cancer tumour microenvironment (TME) treatment resistance radiotherapy radiation radioprotection hypoxia polyurethane scaffolds extracellular matrix (ECM) HIF-1a PANC-1 organoids tumour heterogeneity colorectal neoplasms clonal evolution longitudinal imaging neoplasm recurrence cell lineage self-renewal cell culture techniques 3D cancer models immunotherapies tumor escape mechanisms epithelial ovarian cancer 3D in vitro model chemotherapy Cisplatin spheroids hydrogels polymeric scaffolds A2780 SK-OV-3 fused deposition modeling cancer tissue engineering in vitro model mechanical properties mesenchymal stromal cell bone matrix personalized therapy scaffold primary cancer cells experimental models screening 3Rs tumour modelling polyhydroxyalkanoates (PHAs) colon cancer epithelial-mesenchymal transition (EMT) scaffolds 3D three-dimensional model ovarian cancer patient-derived personalised n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | biomaterials tissue engineering 3D cell culture cancer cells bioprinting breast cancer metastasis bone 3D modeling tumor microenvironment extracellular matrix 3D printing 3D bioprinting bone cancer calcium phosphates bone model orthopedics EGFR trafficking degradation self-assembling peptides 3D culture pancreatic ductal adenocarcinoma PDAC drug resistance 3D tumor model 3D microfiber amoeboid cell migration brain cancer PTEN RHO ROCK durotaxis topotaxis pancreatic cancer tumour microenvironment (TME) treatment resistance radiotherapy radiation radioprotection hypoxia polyurethane scaffolds extracellular matrix (ECM) HIF-1a PANC-1 organoids tumour heterogeneity colorectal neoplasms clonal evolution longitudinal imaging neoplasm recurrence cell lineage self-renewal cell culture techniques 3D cancer models immunotherapies tumor escape mechanisms epithelial ovarian cancer 3D in vitro model chemotherapy Cisplatin spheroids hydrogels polymeric scaffolds A2780 SK-OV-3 fused deposition modeling cancer tissue engineering in vitro model mechanical properties mesenchymal stromal cell bone matrix personalized therapy scaffold primary cancer cells experimental models screening 3Rs tumour modelling polyhydroxyalkanoates (PHAs) colon cancer epithelial-mesenchymal transition (EMT) scaffolds 3D three-dimensional model ovarian cancer patient-derived personalised n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20230405_9783036568423_161 |