Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma
Sarcomas are a group of rare cancers that arise in connective tissues of the body. Surgical resection is pivotal for the management of locoregional disease. In locally advanced or metastatic disease settings, systemic therapy has an important role in the multidisciplinary management of sarcoma. Cyto...
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| Format: | Online |
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| Idioma: | anglès |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Accés en línia: | ONIX_20230405_9783036570150_205 |
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| collection | Directory of Open Access Books |
| description | Sarcomas are a group of rare cancers that arise in connective tissues of the body. Surgical resection is pivotal for the management of locoregional disease. In locally advanced or metastatic disease settings, systemic therapy has an important role in the multidisciplinary management of sarcoma. Cytotoxic therapy has been the primary treatment for many years. However, recent advances in molecular pathogenesis, the investigation of the tumour microenvironment, changes in clinical trial design, and increased international collaboration have led to the development of histology-driven therapy. Furthermore, genomic profiling has highlighted that, while some sarcomas have complex karyotypes, others are driven by translocation, amplification, and mutation, representing targets for the development of novel therapies. Checkpoint inhibitors have been used as single agents or in combination in clinical sarcoma trials. This progress will move the therapeutic modality in sarcoma patients from the “one-size-fits-all” approach towards a more personalized therapeutic algorithm and better outcomes soon. In this Special Issue, we present original research and review articles highlighting novel therapeutic approaches in the treatment of sarcoma patients. |
| format | Online |
| id | doab-20.500.12854ir-98926 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-989262024-03-31T13:10:38Z Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma Szkandera, Joanna Andreou, Dimosthenis osteosarcoma survival prognosis age groups chemotherapy metastasis local recurrence TEM1 VEGFR-1 EGFR VEGFR-2 IGF-1R PDGFRα CD40 image guided surgery near-infra red fluorescence soft tissue sarcomas angiosarcoma paclitaxel pazopanib efficacy toxicity progression-free survival sarcoma radiotherapy neoadjuvant therapy hypofractionated radiotherapy thermotherapy hyperthermia incisional biopsy core needle biopsy sensitivity bone soft tissue LC3B ATG16L1 p62 M6PR PD-L1 CD8 notochord tumor endoprosthesis megaprosthesis periprosthetic joint infection revision surgery bone sarcoma extracellular acidosis tumour microenvironment tumour-associated stroma acid-sensing ion channels vacuolar-ATP-ase carbonic anhydrase IX acridine orange soft tissue sarcoma immune monitoring immunophenotyping cytokines immune checkpoints gene expression Angiosarcoma biomarkers tumor microenvironment immunotherapy next-generation sequencing whole transcriptome sequencing thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Sarcomas are a group of rare cancers that arise in connective tissues of the body. Surgical resection is pivotal for the management of locoregional disease. In locally advanced or metastatic disease settings, systemic therapy has an important role in the multidisciplinary management of sarcoma. Cytotoxic therapy has been the primary treatment for many years. However, recent advances in molecular pathogenesis, the investigation of the tumour microenvironment, changes in clinical trial design, and increased international collaboration have led to the development of histology-driven therapy. Furthermore, genomic profiling has highlighted that, while some sarcomas have complex karyotypes, others are driven by translocation, amplification, and mutation, representing targets for the development of novel therapies. Checkpoint inhibitors have been used as single agents or in combination in clinical sarcoma trials. This progress will move the therapeutic modality in sarcoma patients from the “one-size-fits-all” approach towards a more personalized therapeutic algorithm and better outcomes soon. In this Special Issue, we present original research and review articles highlighting novel therapeutic approaches in the treatment of sarcoma patients. 2023-04-05T12:59:24Z 2023-04-05T12:59:24Z 2023 book ONIX_20230405_9783036570150_205 9783036570150 9783036570143 https://directory.doabooks.org/handle/20.500.12854/98926 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/6979 https://mdpi.com/books/pdfview/book/6979 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7014-3 10.3390/books978-3-0365-7014-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036570150 9783036570143 168 Basel open access |
| spellingShingle | osteosarcoma survival prognosis age groups chemotherapy metastasis local recurrence TEM1 VEGFR-1 EGFR VEGFR-2 IGF-1R PDGFRα CD40 image guided surgery near-infra red fluorescence soft tissue sarcomas angiosarcoma paclitaxel pazopanib efficacy toxicity progression-free survival sarcoma radiotherapy neoadjuvant therapy hypofractionated radiotherapy thermotherapy hyperthermia incisional biopsy core needle biopsy sensitivity bone soft tissue LC3B ATG16L1 p62 M6PR PD-L1 CD8 notochord tumor endoprosthesis megaprosthesis periprosthetic joint infection revision surgery bone sarcoma extracellular acidosis tumour microenvironment tumour-associated stroma acid-sensing ion channels vacuolar-ATP-ase carbonic anhydrase IX acridine orange soft tissue sarcoma immune monitoring immunophenotyping cytokines immune checkpoints gene expression Angiosarcoma biomarkers tumor microenvironment immunotherapy next-generation sequencing whole transcriptome sequencing thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma |
| title | Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma |
| title_full | Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma |
| title_fullStr | Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma |
| title_full_unstemmed | Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma |
| title_short | Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma |
| title_sort | novel therapeutic considerations in bone and soft tissue sarcoma |
| topic | osteosarcoma survival prognosis age groups chemotherapy metastasis local recurrence TEM1 VEGFR-1 EGFR VEGFR-2 IGF-1R PDGFRα CD40 image guided surgery near-infra red fluorescence soft tissue sarcomas angiosarcoma paclitaxel pazopanib efficacy toxicity progression-free survival sarcoma radiotherapy neoadjuvant therapy hypofractionated radiotherapy thermotherapy hyperthermia incisional biopsy core needle biopsy sensitivity bone soft tissue LC3B ATG16L1 p62 M6PR PD-L1 CD8 notochord tumor endoprosthesis megaprosthesis periprosthetic joint infection revision surgery bone sarcoma extracellular acidosis tumour microenvironment tumour-associated stroma acid-sensing ion channels vacuolar-ATP-ase carbonic anhydrase IX acridine orange soft tissue sarcoma immune monitoring immunophenotyping cytokines immune checkpoints gene expression Angiosarcoma biomarkers tumor microenvironment immunotherapy next-generation sequencing whole transcriptome sequencing thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | osteosarcoma survival prognosis age groups chemotherapy metastasis local recurrence TEM1 VEGFR-1 EGFR VEGFR-2 IGF-1R PDGFRα CD40 image guided surgery near-infra red fluorescence soft tissue sarcomas angiosarcoma paclitaxel pazopanib efficacy toxicity progression-free survival sarcoma radiotherapy neoadjuvant therapy hypofractionated radiotherapy thermotherapy hyperthermia incisional biopsy core needle biopsy sensitivity bone soft tissue LC3B ATG16L1 p62 M6PR PD-L1 CD8 notochord tumor endoprosthesis megaprosthesis periprosthetic joint infection revision surgery bone sarcoma extracellular acidosis tumour microenvironment tumour-associated stroma acid-sensing ion channels vacuolar-ATP-ase carbonic anhydrase IX acridine orange soft tissue sarcoma immune monitoring immunophenotyping cytokines immune checkpoints gene expression Angiosarcoma biomarkers tumor microenvironment immunotherapy next-generation sequencing whole transcriptome sequencing thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20230405_9783036570150_205 |