The Fungal Cell Wall Integrity Pathway
Adaptation to external changes is necessary for all cells to survive and thrive in diverse environments. Key to these responses are the MAPK-mediated signaling pathways, intracellular communication routes that sense stimuli at the cell surface, and are ubiquitous in all eukaryotic organisms. In the...
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| Formato: | Online |
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| Idioma: | inglés |
| Publicado: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Acceso en liña: | ONIX_20230405_9783036569734_219 |
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| _version_ | 1869518827550670848 |
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| collection | Directory of Open Access Books |
| description | Adaptation to external changes is necessary for all cells to survive and thrive in diverse environments. Key to these responses are the MAPK-mediated signaling pathways, intracellular communication routes that sense stimuli at the cell surface, and are ubiquitous in all eukaryotic organisms. In the case of fungi, MAPKs mediate essential processes, such as adaptation to environmental stresses, morphology regulation, or developmental processes. First studied in the early nineties in Saccharomyces cerevisiae, the fungal cell wall integrity (CWI) pathway has proven to be a central MAPK-mediated signaling cascade conserved in the fungal kingdom. Cells need to sense cell wall-perturbing conditions and mount the appropriate salvage response. Understanding this CWI pathway-mediated compensatory mechanism is key for the development of cell wall-targeted antifungal therapies. Moreover, its functional roles go beyond the maintenance of this essential structure, reaching many other physiological aspects that have major implications in development or virulence.In this Special Issue, expert researchers in this relevant subject have contributed with seven reviews and eleven original articles to advance our understanding of the CWI pathway by covering different structural, regulatory, and functional aspects in distinct yeasts and filamentous fungi. |
| format | Online |
| id | doab-20.500.12854ir-98940 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-989402024-03-28T03:33:24Z The Fungal Cell Wall Integrity Pathway Molina, María Martín, Humberto Wsc1 membrane sensor SMALP detergent-free extraction fluorescence correlation spectroscopy transmission electron microscopy 3D reconstruction fission yeast MAPK cell integrity pathway S. japonicus S. pombe protein kinase C Pmk1 dimorphism hyphae yeast cell wall integrity phosphorylation azoles clotrimazole cytokinesis actomyosin ring septum cell integrity fungi cell wall cell wall proteins signaling pathways stress tolerance mannoprotein budding yeast morphology CalMorph cell wall integrity (CWI) pathway PKC GTPases MAP kinase morphogenesis virulence pathogenesis Hrr25 Mec1 Tel1 Pkc1 hydroxyurea UV irradiation cell wall integrity (CWI) Mtl1 autophagy glucose mitophagy Saccharomyces cerevisiae histidine kinase Paracoccidioides paracoccidioidomycosis cell cycle Slt2 checkpoint DNA damage conjugation ploidy lysis Cell Integrity Pathway stress CWI pathway UPR glucosamine tunicamycin N-glycosylation cell wall integrity pathway MAPK substrate kinase assay fungal cell wall cysteine-rich domain PAN domain aromatic clusters filamentous fungi signaling pathway surface sensor mitogen-activated protein kinase plant pathogen application fungicide drug target culture productivity stress response screening transcription essential genes n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Adaptation to external changes is necessary for all cells to survive and thrive in diverse environments. Key to these responses are the MAPK-mediated signaling pathways, intracellular communication routes that sense stimuli at the cell surface, and are ubiquitous in all eukaryotic organisms. In the case of fungi, MAPKs mediate essential processes, such as adaptation to environmental stresses, morphology regulation, or developmental processes. First studied in the early nineties in Saccharomyces cerevisiae, the fungal cell wall integrity (CWI) pathway has proven to be a central MAPK-mediated signaling cascade conserved in the fungal kingdom. Cells need to sense cell wall-perturbing conditions and mount the appropriate salvage response. Understanding this CWI pathway-mediated compensatory mechanism is key for the development of cell wall-targeted antifungal therapies. Moreover, its functional roles go beyond the maintenance of this essential structure, reaching many other physiological aspects that have major implications in development or virulence.In this Special Issue, expert researchers in this relevant subject have contributed with seven reviews and eleven original articles to advance our understanding of the CWI pathway by covering different structural, regulatory, and functional aspects in distinct yeasts and filamentous fungi. 2023-04-05T13:00:06Z 2023-04-05T13:00:06Z 2023 book ONIX_20230405_9783036569734_219 9783036569734 9783036569727 https://directory.doabooks.org/handle/20.500.12854/98940 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/6993 https://mdpi.com/books/pdfview/book/6993 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6972-7 10.3390/books978-3-0365-6972-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036569734 9783036569727 392 Basel open access |
| spellingShingle | Wsc1 membrane sensor SMALP detergent-free extraction fluorescence correlation spectroscopy transmission electron microscopy 3D reconstruction fission yeast MAPK cell integrity pathway S. japonicus S. pombe protein kinase C Pmk1 dimorphism hyphae yeast cell wall integrity phosphorylation azoles clotrimazole cytokinesis actomyosin ring septum cell integrity fungi cell wall cell wall proteins signaling pathways stress tolerance mannoprotein budding yeast morphology CalMorph cell wall integrity (CWI) pathway PKC GTPases MAP kinase morphogenesis virulence pathogenesis Hrr25 Mec1 Tel1 Pkc1 hydroxyurea UV irradiation cell wall integrity (CWI) Mtl1 autophagy glucose mitophagy Saccharomyces cerevisiae histidine kinase Paracoccidioides paracoccidioidomycosis cell cycle Slt2 checkpoint DNA damage conjugation ploidy lysis Cell Integrity Pathway stress CWI pathway UPR glucosamine tunicamycin N-glycosylation cell wall integrity pathway MAPK substrate kinase assay fungal cell wall cysteine-rich domain PAN domain aromatic clusters filamentous fungi signaling pathway surface sensor mitogen-activated protein kinase plant pathogen application fungicide drug target culture productivity stress response screening transcription essential genes n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The Fungal Cell Wall Integrity Pathway |
| title | The Fungal Cell Wall Integrity Pathway |
| title_full | The Fungal Cell Wall Integrity Pathway |
| title_fullStr | The Fungal Cell Wall Integrity Pathway |
| title_full_unstemmed | The Fungal Cell Wall Integrity Pathway |
| title_short | The Fungal Cell Wall Integrity Pathway |
| title_sort | fungal cell wall integrity pathway |
| topic | Wsc1 membrane sensor SMALP detergent-free extraction fluorescence correlation spectroscopy transmission electron microscopy 3D reconstruction fission yeast MAPK cell integrity pathway S. japonicus S. pombe protein kinase C Pmk1 dimorphism hyphae yeast cell wall integrity phosphorylation azoles clotrimazole cytokinesis actomyosin ring septum cell integrity fungi cell wall cell wall proteins signaling pathways stress tolerance mannoprotein budding yeast morphology CalMorph cell wall integrity (CWI) pathway PKC GTPases MAP kinase morphogenesis virulence pathogenesis Hrr25 Mec1 Tel1 Pkc1 hydroxyurea UV irradiation cell wall integrity (CWI) Mtl1 autophagy glucose mitophagy Saccharomyces cerevisiae histidine kinase Paracoccidioides paracoccidioidomycosis cell cycle Slt2 checkpoint DNA damage conjugation ploidy lysis Cell Integrity Pathway stress CWI pathway UPR glucosamine tunicamycin N-glycosylation cell wall integrity pathway MAPK substrate kinase assay fungal cell wall cysteine-rich domain PAN domain aromatic clusters filamentous fungi signaling pathway surface sensor mitogen-activated protein kinase plant pathogen application fungicide drug target culture productivity stress response screening transcription essential genes n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Wsc1 membrane sensor SMALP detergent-free extraction fluorescence correlation spectroscopy transmission electron microscopy 3D reconstruction fission yeast MAPK cell integrity pathway S. japonicus S. pombe protein kinase C Pmk1 dimorphism hyphae yeast cell wall integrity phosphorylation azoles clotrimazole cytokinesis actomyosin ring septum cell integrity fungi cell wall cell wall proteins signaling pathways stress tolerance mannoprotein budding yeast morphology CalMorph cell wall integrity (CWI) pathway PKC GTPases MAP kinase morphogenesis virulence pathogenesis Hrr25 Mec1 Tel1 Pkc1 hydroxyurea UV irradiation cell wall integrity (CWI) Mtl1 autophagy glucose mitophagy Saccharomyces cerevisiae histidine kinase Paracoccidioides paracoccidioidomycosis cell cycle Slt2 checkpoint DNA damage conjugation ploidy lysis Cell Integrity Pathway stress CWI pathway UPR glucosamine tunicamycin N-glycosylation cell wall integrity pathway MAPK substrate kinase assay fungal cell wall cysteine-rich domain PAN domain aromatic clusters filamentous fungi signaling pathway surface sensor mitogen-activated protein kinase plant pathogen application fungicide drug target culture productivity stress response screening transcription essential genes n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230405_9783036569734_219 |