Neurodegenerative Diseases
Neurodegenerative diseases (NDs) are a heterogeneous group of complex diseases characterized by neuronal loss and progressive degeneration of different areas of the nervous system. NDs represent a significant health problem worldwide, with an increasing incidence rate. Although the exact pathogenesi...
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| Format: | Online |
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| Sprache: | Englisch |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online-Zugang: | ONIX_20230405_9783036570754_235 |
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| description | Neurodegenerative diseases (NDs) are a heterogeneous group of complex diseases characterized by neuronal loss and progressive degeneration of different areas of the nervous system. NDs represent a significant health problem worldwide, with an increasing incidence rate. Although the exact pathogenesis of NDs remains unclear, a complex interaction among genetic, epigenetic, and environmental factors has been proposed. To date, no effective therapeutics have been developed to slow, halt, or prevent any NDs. Thus, information on the molecular mechanisms underlying the pathogenesis of NDs is strongly sought after. This Special Issue collected papers discussing advances in the field of NDs. |
| format | Online |
| id | doab-20.500.12854ir-98956 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-989562024-03-28T03:31:12Z Neurodegenerative Diseases Ciaccio, Marcello Agnello, Luisa menopause estrogen neurodegenerative disease Alzheimer’s disease IGF-1 NMDAR Parkinson’s disease neurodegeneration genetics non-coding RNAs microbiome mitochondria epigenetics biomarkers precision medicine EAE glutamate receptor antagonist excitotoxicity oxidative stress -SH groups superoxide dismutase circulating microRNA relapsing–remitting multiple sclerosis secondary progressive multiple sclerosis biomarker neuroinflammation Rab1 GTPases secretory pathway Golgi fragmentation autophagy α-synuclein LRRK2 mercury central nervous system proteomic motor functions rotenone dopamine dopamine-D3-receptor buspirone chicoric acid peripheral immune system spleen gut 6-hydroxydopamine apoptosis mitochondrial membrane potential neurodegenerative diseases cell culture techniques neurodegenerative disorders neuroprotective effect biological products striatum caspase-3 spiny projection neurons dendritic spines long-term depression Q-VD-OPh mice blood–brain barrier extracellular matrix fibronectin liposomes multiple sclerosis nanomedicine oligodendrocytes PLGA remyelination therapeutic targets n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Neurodegenerative diseases (NDs) are a heterogeneous group of complex diseases characterized by neuronal loss and progressive degeneration of different areas of the nervous system. NDs represent a significant health problem worldwide, with an increasing incidence rate. Although the exact pathogenesis of NDs remains unclear, a complex interaction among genetic, epigenetic, and environmental factors has been proposed. To date, no effective therapeutics have been developed to slow, halt, or prevent any NDs. Thus, information on the molecular mechanisms underlying the pathogenesis of NDs is strongly sought after. This Special Issue collected papers discussing advances in the field of NDs. 2023-04-05T13:00:54Z 2023-04-05T13:00:54Z 2023 book ONIX_20230405_9783036570754_235 9783036570754 9783036570747 https://directory.doabooks.org/handle/20.500.12854/98956 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/7009 https://mdpi.com/books/pdfview/book/7009 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7074-7 10.3390/books978-3-0365-7074-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036570754 9783036570747 262 Basel open access |
| spellingShingle | menopause estrogen neurodegenerative disease Alzheimer’s disease IGF-1 NMDAR Parkinson’s disease neurodegeneration genetics non-coding RNAs microbiome mitochondria epigenetics biomarkers precision medicine EAE glutamate receptor antagonist excitotoxicity oxidative stress -SH groups superoxide dismutase circulating microRNA relapsing–remitting multiple sclerosis secondary progressive multiple sclerosis biomarker neuroinflammation Rab1 GTPases secretory pathway Golgi fragmentation autophagy α-synuclein LRRK2 mercury central nervous system proteomic motor functions rotenone dopamine dopamine-D3-receptor buspirone chicoric acid peripheral immune system spleen gut 6-hydroxydopamine apoptosis mitochondrial membrane potential neurodegenerative diseases cell culture techniques neurodegenerative disorders neuroprotective effect biological products striatum caspase-3 spiny projection neurons dendritic spines long-term depression Q-VD-OPh mice blood–brain barrier extracellular matrix fibronectin liposomes multiple sclerosis nanomedicine oligodendrocytes PLGA remyelination therapeutic targets n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Neurodegenerative Diseases |
| title | Neurodegenerative Diseases |
| title_full | Neurodegenerative Diseases |
| title_fullStr | Neurodegenerative Diseases |
| title_full_unstemmed | Neurodegenerative Diseases |
| title_short | Neurodegenerative Diseases |
| title_sort | neurodegenerative diseases |
| topic | menopause estrogen neurodegenerative disease Alzheimer’s disease IGF-1 NMDAR Parkinson’s disease neurodegeneration genetics non-coding RNAs microbiome mitochondria epigenetics biomarkers precision medicine EAE glutamate receptor antagonist excitotoxicity oxidative stress -SH groups superoxide dismutase circulating microRNA relapsing–remitting multiple sclerosis secondary progressive multiple sclerosis biomarker neuroinflammation Rab1 GTPases secretory pathway Golgi fragmentation autophagy α-synuclein LRRK2 mercury central nervous system proteomic motor functions rotenone dopamine dopamine-D3-receptor buspirone chicoric acid peripheral immune system spleen gut 6-hydroxydopamine apoptosis mitochondrial membrane potential neurodegenerative diseases cell culture techniques neurodegenerative disorders neuroprotective effect biological products striatum caspase-3 spiny projection neurons dendritic spines long-term depression Q-VD-OPh mice blood–brain barrier extracellular matrix fibronectin liposomes multiple sclerosis nanomedicine oligodendrocytes PLGA remyelination therapeutic targets n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | menopause estrogen neurodegenerative disease Alzheimer’s disease IGF-1 NMDAR Parkinson’s disease neurodegeneration genetics non-coding RNAs microbiome mitochondria epigenetics biomarkers precision medicine EAE glutamate receptor antagonist excitotoxicity oxidative stress -SH groups superoxide dismutase circulating microRNA relapsing–remitting multiple sclerosis secondary progressive multiple sclerosis biomarker neuroinflammation Rab1 GTPases secretory pathway Golgi fragmentation autophagy α-synuclein LRRK2 mercury central nervous system proteomic motor functions rotenone dopamine dopamine-D3-receptor buspirone chicoric acid peripheral immune system spleen gut 6-hydroxydopamine apoptosis mitochondrial membrane potential neurodegenerative diseases cell culture techniques neurodegenerative disorders neuroprotective effect biological products striatum caspase-3 spiny projection neurons dendritic spines long-term depression Q-VD-OPh mice blood–brain barrier extracellular matrix fibronectin liposomes multiple sclerosis nanomedicine oligodendrocytes PLGA remyelination therapeutic targets n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | ONIX_20230405_9783036570754_235 |