Controversies and Recent Advances in Senescence and Aging
This reprint is a compilation of the articles and reviews published in the Special issue entitled "Controversies and Recent Advances in Senescence and Aging" in Cells. The Editorial summarises and highlights the contents of the published articles. Aging is the leading predictive factor of many chron...
I tiakina i:
| Hōputu: | Online |
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| Reo: | Ingarihi |
| I whakaputaina: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Ngā marau: | |
| Urunga tuihono: | ONIX_20230511_9783036571690_10 |
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Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869529202024251392 |
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| collection | Directory of Open Access Books |
| description | This reprint is a compilation of the articles and reviews published in the Special issue entitled "Controversies and Recent Advances in Senescence and Aging" in Cells. The Editorial summarises and highlights the contents of the published articles. Aging is the leading predictive factor of many chronic diseases that account for most of the morbidity and mortality worldwide, i.e., neurodegeneration, cardiovascular, pulmonary, renal, and bone diseases, as well as cancers. Oxidative stress and reactive oxygen species generation, the over-production of inflammatory cytokines, the activation of oncogenes, DNA damage, telomere shortening, and the accumulation of senescent cells are all widely accepted mechanisms contributing to aging. Senescence is mainly thought to be provoked by negative cellular stress but might also be induced by physiological developmental stimuli. Senescence is characterized by irreversible cell cycle arrest independent of quiescence and terminal differentiation. The Special Issue entitled “Controversies and Recent Advances in Senescence and Aging”, which is contained in this reprint, comprises an excellent collection of original articles and reviews highlighting different novel aspects in the fields of senescence and aging research. They will hopefully stimulate discussions and further research in these fields, which are extremely important in a constantly aging human population. |
| format | Online |
| id | doab-20.500.12854ir-99993 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-999932024-03-28T03:33:55Z Controversies and Recent Advances in Senescence and Aging Wagner, Nicole Wagner, Kay-Dietrich aging endothelial cells development liver heart brain kidney senescence SASP ageing senolytics/senostatics p16Ink4a p19Arf p21Waf1/Cip1 replicative senescence DNA damage response telomerase and telomeres TGF-β signalling pulmonary fibrosis COVID-19 natural killer cells (NK cells) immunosenescence elderly frailty cytokines inflammation immune system sarcopenia NLRP pyroptosis gasdermin aging-related disease mouse model melanocyte melanoma beta-galactosidase telomerase/hTERT anti-cancer sanguinarine chloride cellular senescence multinucleation retinal pigment epithelium reactive oxygen species photoreceptor DNA damage p53 telomeres telomerase shelterin moderate exercise high-fat diet Sprague Dawley rats lung diseases asthma COPD remodeling mitochondrial dysfunction metabolic function stem cells lysosome lifespan duox ROS Drosophila melanogaster air pollution skin aging cosmetics short-chain fatty acids neutrophil HIV women n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This reprint is a compilation of the articles and reviews published in the Special issue entitled "Controversies and Recent Advances in Senescence and Aging" in Cells. The Editorial summarises and highlights the contents of the published articles. Aging is the leading predictive factor of many chronic diseases that account for most of the morbidity and mortality worldwide, i.e., neurodegeneration, cardiovascular, pulmonary, renal, and bone diseases, as well as cancers. Oxidative stress and reactive oxygen species generation, the over-production of inflammatory cytokines, the activation of oncogenes, DNA damage, telomere shortening, and the accumulation of senescent cells are all widely accepted mechanisms contributing to aging. Senescence is mainly thought to be provoked by negative cellular stress but might also be induced by physiological developmental stimuli. Senescence is characterized by irreversible cell cycle arrest independent of quiescence and terminal differentiation. The Special Issue entitled “Controversies and Recent Advances in Senescence and Aging”, which is contained in this reprint, comprises an excellent collection of original articles and reviews highlighting different novel aspects in the fields of senescence and aging research. They will hopefully stimulate discussions and further research in these fields, which are extremely important in a constantly aging human population. 2023-05-11T17:15:44Z 2023-05-11T17:15:44Z 2023 book ONIX_20230511_9783036571690_10 9783036571690 9783036571683 https://directory.doabooks.org/handle/20.500.12854/99993 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7086 https://mdpi.com/books/pdfview/book/7086 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7168-3 10.3390/books978-3-0365-7168-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036571690 9783036571683 320 Basel open access |
| spellingShingle | aging endothelial cells development liver heart brain kidney senescence SASP ageing senolytics/senostatics p16Ink4a p19Arf p21Waf1/Cip1 replicative senescence DNA damage response telomerase and telomeres TGF-β signalling pulmonary fibrosis COVID-19 natural killer cells (NK cells) immunosenescence elderly frailty cytokines inflammation immune system sarcopenia NLRP pyroptosis gasdermin aging-related disease mouse model melanocyte melanoma beta-galactosidase telomerase/hTERT anti-cancer sanguinarine chloride cellular senescence multinucleation retinal pigment epithelium reactive oxygen species photoreceptor DNA damage p53 telomeres telomerase shelterin moderate exercise high-fat diet Sprague Dawley rats lung diseases asthma COPD remodeling mitochondrial dysfunction metabolic function stem cells lysosome lifespan duox ROS Drosophila melanogaster air pollution skin aging cosmetics short-chain fatty acids neutrophil HIV women n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Controversies and Recent Advances in Senescence and Aging |
| title | Controversies and Recent Advances in Senescence and Aging |
| title_full | Controversies and Recent Advances in Senescence and Aging |
| title_fullStr | Controversies and Recent Advances in Senescence and Aging |
| title_full_unstemmed | Controversies and Recent Advances in Senescence and Aging |
| title_short | Controversies and Recent Advances in Senescence and Aging |
| title_sort | controversies and recent advances in senescence and aging |
| topic | aging endothelial cells development liver heart brain kidney senescence SASP ageing senolytics/senostatics p16Ink4a p19Arf p21Waf1/Cip1 replicative senescence DNA damage response telomerase and telomeres TGF-β signalling pulmonary fibrosis COVID-19 natural killer cells (NK cells) immunosenescence elderly frailty cytokines inflammation immune system sarcopenia NLRP pyroptosis gasdermin aging-related disease mouse model melanocyte melanoma beta-galactosidase telomerase/hTERT anti-cancer sanguinarine chloride cellular senescence multinucleation retinal pigment epithelium reactive oxygen species photoreceptor DNA damage p53 telomeres telomerase shelterin moderate exercise high-fat diet Sprague Dawley rats lung diseases asthma COPD remodeling mitochondrial dysfunction metabolic function stem cells lysosome lifespan duox ROS Drosophila melanogaster air pollution skin aging cosmetics short-chain fatty acids neutrophil HIV women n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | aging endothelial cells development liver heart brain kidney senescence SASP ageing senolytics/senostatics p16Ink4a p19Arf p21Waf1/Cip1 replicative senescence DNA damage response telomerase and telomeres TGF-β signalling pulmonary fibrosis COVID-19 natural killer cells (NK cells) immunosenescence elderly frailty cytokines inflammation immune system sarcopenia NLRP pyroptosis gasdermin aging-related disease mouse model melanocyte melanoma beta-galactosidase telomerase/hTERT anti-cancer sanguinarine chloride cellular senescence multinucleation retinal pigment epithelium reactive oxygen species photoreceptor DNA damage p53 telomeres telomerase shelterin moderate exercise high-fat diet Sprague Dawley rats lung diseases asthma COPD remodeling mitochondrial dysfunction metabolic function stem cells lysosome lifespan duox ROS Drosophila melanogaster air pollution skin aging cosmetics short-chain fatty acids neutrophil HIV women n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230511_9783036571690_10 |