Novel Approaches in Mycotoxins Research
Mycotoxins—harmful compounds produced by fungi—pose serious threats to food safety and public health. This Special Issue compiles research addressing their detection, toxic effects, and mitigation. Studies have revealed that Fusarium verticillioides resists fumonisins through ceramide synthase overe...
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| Format: | Online |
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| Sprache: | Englisch |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Online-Zugang: | ONIX_20250812T110751_9783725842339_389 |
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| description | Mycotoxins—harmful compounds produced by fungi—pose serious threats to food safety and public health. This Special Issue compiles research addressing their detection, toxic effects, and mitigation. Studies have revealed that Fusarium verticillioides resists fumonisins through ceramide synthase overexpression (FUM18), and a new HPLC-FLD method now allows precise OTA measurement in mouse brain and intestine tissues. In the past, Mycotoxin contamination in hops used for brewing was widespread, though controlled storage limited some risks. Since then, machine learning models have emerged as promising tools for rapid detection, albeit with reproducibility challenges. Protective agents like quercetin, fermented whey, and plant polyphenols (e.g., catechin, epicatechin) have also demonstrated the ability to counteract mycotoxin toxicity, and research has shown that mycotoxins' stability in food varies over time and that co-ingestion factors like milk can alter absorption. The combined toxicity of mycotoxins with compounds like acrylamide may increase neurological risks, highlighting the need for deeper investigation. Despite progress, significant gaps remain in assessing human exposure, developing validated biomarkers, and using advanced human-relevant models, emphasizing the need for interdisciplinary efforts to improve risk assessment and mitigation. |
| format | Online |
| id | doab-20.500.12854ir-165634 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
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| spelling | doab-20.500.12854ir-1656342025-08-12T10:02:14Z Novel Approaches in Mycotoxins Research Jakšić, Daniela Juan-García, Ana food contaminants mycotoxins digestion mixtures mode of action thema EDItEUR::M Medicine and Nursing Mycotoxins—harmful compounds produced by fungi—pose serious threats to food safety and public health. This Special Issue compiles research addressing their detection, toxic effects, and mitigation. Studies have revealed that Fusarium verticillioides resists fumonisins through ceramide synthase overexpression (FUM18), and a new HPLC-FLD method now allows precise OTA measurement in mouse brain and intestine tissues. In the past, Mycotoxin contamination in hops used for brewing was widespread, though controlled storage limited some risks. Since then, machine learning models have emerged as promising tools for rapid detection, albeit with reproducibility challenges. Protective agents like quercetin, fermented whey, and plant polyphenols (e.g., catechin, epicatechin) have also demonstrated the ability to counteract mycotoxin toxicity, and research has shown that mycotoxins' stability in food varies over time and that co-ingestion factors like milk can alter absorption. The combined toxicity of mycotoxins with compounds like acrylamide may increase neurological risks, highlighting the need for deeper investigation. Despite progress, significant gaps remain in assessing human exposure, developing validated biomarkers, and using advanced human-relevant models, emphasizing the need for interdisciplinary efforts to improve risk assessment and mitigation. 2025-08-12T10:02:11Z 2025-08-12T10:02:11Z 2025 book ONIX_20250812T110751_9783725842339_389 9783725842339 9783725842346 https://directory.doabooks.org/handle/20.500.12854/165634 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/11068 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-4234-6 10.3390/books978-3-7258-4234-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725842339 9783725842346 202 open access |
| spellingShingle | food contaminants mycotoxins digestion mixtures mode of action thema EDItEUR::M Medicine and Nursing Novel Approaches in Mycotoxins Research |
| title | Novel Approaches in Mycotoxins Research |
| title_full | Novel Approaches in Mycotoxins Research |
| title_fullStr | Novel Approaches in Mycotoxins Research |
| title_full_unstemmed | Novel Approaches in Mycotoxins Research |
| title_short | Novel Approaches in Mycotoxins Research |
| title_sort | novel approaches in mycotoxins research |
| topic | food contaminants mycotoxins digestion mixtures mode of action thema EDItEUR::M Medicine and Nursing |
| topic_facet | food contaminants mycotoxins digestion mixtures mode of action thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20250812T110751_9783725842339_389 |