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Chapter 15 Brain Tumors and the Lynch Syndrome

Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and...

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Gardado en:
Main Authors: Peltomäki, Päivi, Gylling, Annette
Formato: Online
Idioma:inglés
Publicado: InTechOpen 2021
Subjects:
brain tumors
lynch syndrome
Colorectal cancer
DNA methylation
DNA mismatch repair
Gene
Glioblastoma
Glioma
Hereditary nonpolyposis colorectal cancer
Mutation
Neoplasm
Acceso en liña:612584
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Summary:Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal cancers (Lynch & de la Chapelle, 2003).

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