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Heparan Sulfate Proteoglycans and Their Endogenous Modifying Enzymes: Cancer Players, Biomarkers and Therapeutic Targets

In recent decades, evidence has accumulated implicating heparan sulfate proteoglycans (HSPGs) in tumor initiation and progression. Ubiquitously present at the cell surface and in the extracellular matrix, HSPGs are composed of a protein core with covalently bound heparan sulfate (HS) chains. They pr...

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Salvato in:
Natura: Online
Lingua:inglese
Pubblicazione: Frontiers Media SA 2021
Soggetti:
heparan sulfate proteoglycan
heparanase
sulfotransferase
glypican
cancer therapy
thema EDItEUR::M Medicine and Nursing
thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
Accesso online:ONIX_20211118_9782889636167_890
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