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The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria

Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby...

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Gorde:
Formatua: Online
Hizkuntza:ingelesa
Argitaratua: MDPI - Multidisciplinary Digital Publishing Institute 2022
Gaiak:
MdtF (YhiV)
multidrug resistance
RND-type efflux pump
dye accumulation
real-time efflux
pathogens
RND
evolution
efflux pump
adaptation
Aliarcobacter butzleri
RND efflux pumps
virulence
resistance
RND pump
dominant negative effect
assembly
protein-protein interaction
mutation
drug resistance
cystic fibrosis
prevalence of efflux resistance mechanisms
hospital acquired infections
antibiotic resistance
allostery
antimicrobial resistance
conformational changes
energetic transition
gram-negative bacteria
pump activation
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
Sarrera elektronikoa:ONIX_20220506_9783036539461_112
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Gaia:Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens.

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