The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria
Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby...
-д хадгалсан:
| Формат: | Online |
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| Хэл сонгох: | англи |
| Хэвлэсэн: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Нөхцлүүд: | |
| Онлайн хандалт: | ONIX_20220506_9783036539461_112 |
| Шошгууд: |
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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| _version_ | 1869524803299311616 |
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| collection | Directory of Open Access Books |
| description | Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens. |
| format | Online |
| id | doab-20.500.12854ir-81046 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-810462024-03-28T03:31:15Z The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria Broutin, Isabelle Vargiu, Attilio V Venter, Henrietta Phan, Gilles MdtF (YhiV) multidrug resistance RND-type efflux pump dye accumulation real-time efflux pathogens RND evolution efflux pump adaptation Aliarcobacter butzleri RND efflux pumps virulence resistance RND pump dominant negative effect assembly protein-protein interaction mutation drug resistance cystic fibrosis prevalence of efflux resistance mechanisms hospital acquired infections antibiotic resistance allostery antimicrobial resistance conformational changes energetic transition gram-negative bacteria pump activation n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens. 2022-05-06T11:24:21Z 2022-05-06T11:24:21Z 2022 book ONIX_20220506_9783036539461_112 9783036539461 9783036539454 https://directory.doabooks.org/handle/20.500.12854/81046 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/5388 https://mdpi.com/books/pdfview/book/5388 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3945-4 10.3390/books978-3-0365-3945-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036539461 9783036539454 190 Basel open access |
| spellingShingle | MdtF (YhiV) multidrug resistance RND-type efflux pump dye accumulation real-time efflux pathogens RND evolution efflux pump adaptation Aliarcobacter butzleri RND efflux pumps virulence resistance RND pump dominant negative effect assembly protein-protein interaction mutation drug resistance cystic fibrosis prevalence of efflux resistance mechanisms hospital acquired infections antibiotic resistance allostery antimicrobial resistance conformational changes energetic transition gram-negative bacteria pump activation n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title | The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_full | The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_fullStr | The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_full_unstemmed | The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_short | The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_sort | structural and functional study of efflux pumps belonging to the rnd transporters family from gram negative bacteria |
| topic | MdtF (YhiV) multidrug resistance RND-type efflux pump dye accumulation real-time efflux pathogens RND evolution efflux pump adaptation Aliarcobacter butzleri RND efflux pumps virulence resistance RND pump dominant negative effect assembly protein-protein interaction mutation drug resistance cystic fibrosis prevalence of efflux resistance mechanisms hospital acquired infections antibiotic resistance allostery antimicrobial resistance conformational changes energetic transition gram-negative bacteria pump activation n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | MdtF (YhiV) multidrug resistance RND-type efflux pump dye accumulation real-time efflux pathogens RND evolution efflux pump adaptation Aliarcobacter butzleri RND efflux pumps virulence resistance RND pump dominant negative effect assembly protein-protein interaction mutation drug resistance cystic fibrosis prevalence of efflux resistance mechanisms hospital acquired infections antibiotic resistance allostery antimicrobial resistance conformational changes energetic transition gram-negative bacteria pump activation n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | ONIX_20220506_9783036539461_112 |