Advanced Blood-Brain Barrier Drug Delivery
Advanced Blood-Brain Barrier Drug Delivery is a reprint with a summary editorial, followed by 16 chapters that cover five areas of brain drug delivery, including receptor-mediated transport (RMT), carrier-mediated transport (CMT), active efflux transport (AET), Trojan horse lipid nanoparticles (LNP)...
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| Format: | Online |
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| Jezik: | engleski |
| Izdano: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Teme: | |
| Online pristup: | ONIX_20230202_9783036564173_130 |
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Bez oznaka, Budi prvi tko označuje ovaj zapis!
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| _version_ | 1869521210670317568 |
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| collection | Directory of Open Access Books |
| description | Advanced Blood-Brain Barrier Drug Delivery is a reprint with a summary editorial, followed by 16 chapters that cover five areas of brain drug delivery, including receptor-mediated transport (RMT), carrier-mediated transport (CMT), active efflux transport (AET), Trojan horse lipid nanoparticles (LNP), and in vivo methods for measurement of drug transport across the blood–brain barrier (BBB). |
| format | Online |
| id | doab-20.500.12854ir-96729 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-967292024-03-31T13:08:11Z Advanced Blood-Brain Barrier Drug Delivery Pardridge, William M. blood–brain barrier (BBB) brain drug delivery prodrugs solute carriers (SLCs) lysosomal storage disease neuronopathic mucopolysaccharidosis blood–brain barrier neurodegeneration enzyme replacement therapy receptor-mediated transcytosis transferrin receptor insulin receptor endothelium receptor-mediated transport carrier-mediated transport genetic engineering IgG fusion proteins nanoparticles liposomes TrkB agonist antibody variable new antigen receptor (VNAR) neuroprotection transferrin receptor 1 (TfR1) blood-brain barrier (BBB) 6-OHDA Parkinson’s disease bispecific antibody alpha-synuclein (αSYN) Parkinson’s disease (PD) immunotherapy monoclonal antibody transferrin receptor (TfR) receptor-mediated transcytosis (RMT) single domains antibody IGF1R neurotensin protein-based therapy lysosomal storage disorders fusion proteins Alzheimer’s disease neurotrophic factors decoy receptors ATP-binding cassette transporters drug delivery ischemic stroke SLC transporters lipid nanoparticle ssPalm mRNA transfection hCMEC/D3 cells cell toxicity SWATH-MS translation chaperonin-containing TCP-1 proton-coupled organic cation antiporter photo-affinity labeling proteomics SWATH-MS (sequential window acquisition of all theoretical-mass spectra) pharmacokinetics compartmental models physiologically based PK models blood-brain barrier antibody cavernous sinus BBB–peptide shuttle brain delivery solute carrier (SLC) transporters amyotrophic lateral sclerosis (ALS) NSC-34 cell lines taurine transporter (Taut) large amino acid transporter 1 (LAT1) monocarboxylate transporters (MCTs) organic cation transporters (OCTNs) choline transporter-like protein-1 (CTL1) TNF-α inhibitor molecular Trojan horse endosomal liposome nanoparticle targeting transferrin n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Advanced Blood-Brain Barrier Drug Delivery is a reprint with a summary editorial, followed by 16 chapters that cover five areas of brain drug delivery, including receptor-mediated transport (RMT), carrier-mediated transport (CMT), active efflux transport (AET), Trojan horse lipid nanoparticles (LNP), and in vivo methods for measurement of drug transport across the blood–brain barrier (BBB). 2023-02-02T16:44:46Z 2023-02-02T16:44:46Z 2023 book ONIX_20230202_9783036564173_130 9783036564173 9783036564166 https://directory.doabooks.org/handle/20.500.12854/96729 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6675 https://mdpi.com/books/pdfview/book/6675 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6416-6 10.3390/books978-3-0365-6416-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036564173 9783036564166 496 Basel open access |
| spellingShingle | blood–brain barrier (BBB) brain drug delivery prodrugs solute carriers (SLCs) lysosomal storage disease neuronopathic mucopolysaccharidosis blood–brain barrier neurodegeneration enzyme replacement therapy receptor-mediated transcytosis transferrin receptor insulin receptor endothelium receptor-mediated transport carrier-mediated transport genetic engineering IgG fusion proteins nanoparticles liposomes TrkB agonist antibody variable new antigen receptor (VNAR) neuroprotection transferrin receptor 1 (TfR1) blood-brain barrier (BBB) 6-OHDA Parkinson’s disease bispecific antibody alpha-synuclein (αSYN) Parkinson’s disease (PD) immunotherapy monoclonal antibody transferrin receptor (TfR) receptor-mediated transcytosis (RMT) single domains antibody IGF1R neurotensin protein-based therapy lysosomal storage disorders fusion proteins Alzheimer’s disease neurotrophic factors decoy receptors ATP-binding cassette transporters drug delivery ischemic stroke SLC transporters lipid nanoparticle ssPalm mRNA transfection hCMEC/D3 cells cell toxicity SWATH-MS translation chaperonin-containing TCP-1 proton-coupled organic cation antiporter photo-affinity labeling proteomics SWATH-MS (sequential window acquisition of all theoretical-mass spectra) pharmacokinetics compartmental models physiologically based PK models blood-brain barrier antibody cavernous sinus BBB–peptide shuttle brain delivery solute carrier (SLC) transporters amyotrophic lateral sclerosis (ALS) NSC-34 cell lines taurine transporter (Taut) large amino acid transporter 1 (LAT1) monocarboxylate transporters (MCTs) organic cation transporters (OCTNs) choline transporter-like protein-1 (CTL1) TNF-α inhibitor molecular Trojan horse endosomal liposome nanoparticle targeting transferrin n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Advanced Blood-Brain Barrier Drug Delivery |
| title | Advanced Blood-Brain Barrier Drug Delivery |
| title_full | Advanced Blood-Brain Barrier Drug Delivery |
| title_fullStr | Advanced Blood-Brain Barrier Drug Delivery |
| title_full_unstemmed | Advanced Blood-Brain Barrier Drug Delivery |
| title_short | Advanced Blood-Brain Barrier Drug Delivery |
| title_sort | advanced blood brain barrier drug delivery |
| topic | blood–brain barrier (BBB) brain drug delivery prodrugs solute carriers (SLCs) lysosomal storage disease neuronopathic mucopolysaccharidosis blood–brain barrier neurodegeneration enzyme replacement therapy receptor-mediated transcytosis transferrin receptor insulin receptor endothelium receptor-mediated transport carrier-mediated transport genetic engineering IgG fusion proteins nanoparticles liposomes TrkB agonist antibody variable new antigen receptor (VNAR) neuroprotection transferrin receptor 1 (TfR1) blood-brain barrier (BBB) 6-OHDA Parkinson’s disease bispecific antibody alpha-synuclein (αSYN) Parkinson’s disease (PD) immunotherapy monoclonal antibody transferrin receptor (TfR) receptor-mediated transcytosis (RMT) single domains antibody IGF1R neurotensin protein-based therapy lysosomal storage disorders fusion proteins Alzheimer’s disease neurotrophic factors decoy receptors ATP-binding cassette transporters drug delivery ischemic stroke SLC transporters lipid nanoparticle ssPalm mRNA transfection hCMEC/D3 cells cell toxicity SWATH-MS translation chaperonin-containing TCP-1 proton-coupled organic cation antiporter photo-affinity labeling proteomics SWATH-MS (sequential window acquisition of all theoretical-mass spectra) pharmacokinetics compartmental models physiologically based PK models blood-brain barrier antibody cavernous sinus BBB–peptide shuttle brain delivery solute carrier (SLC) transporters amyotrophic lateral sclerosis (ALS) NSC-34 cell lines taurine transporter (Taut) large amino acid transporter 1 (LAT1) monocarboxylate transporters (MCTs) organic cation transporters (OCTNs) choline transporter-like protein-1 (CTL1) TNF-α inhibitor molecular Trojan horse endosomal liposome nanoparticle targeting transferrin n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | blood–brain barrier (BBB) brain drug delivery prodrugs solute carriers (SLCs) lysosomal storage disease neuronopathic mucopolysaccharidosis blood–brain barrier neurodegeneration enzyme replacement therapy receptor-mediated transcytosis transferrin receptor insulin receptor endothelium receptor-mediated transport carrier-mediated transport genetic engineering IgG fusion proteins nanoparticles liposomes TrkB agonist antibody variable new antigen receptor (VNAR) neuroprotection transferrin receptor 1 (TfR1) blood-brain barrier (BBB) 6-OHDA Parkinson’s disease bispecific antibody alpha-synuclein (αSYN) Parkinson’s disease (PD) immunotherapy monoclonal antibody transferrin receptor (TfR) receptor-mediated transcytosis (RMT) single domains antibody IGF1R neurotensin protein-based therapy lysosomal storage disorders fusion proteins Alzheimer’s disease neurotrophic factors decoy receptors ATP-binding cassette transporters drug delivery ischemic stroke SLC transporters lipid nanoparticle ssPalm mRNA transfection hCMEC/D3 cells cell toxicity SWATH-MS translation chaperonin-containing TCP-1 proton-coupled organic cation antiporter photo-affinity labeling proteomics SWATH-MS (sequential window acquisition of all theoretical-mass spectra) pharmacokinetics compartmental models physiologically based PK models blood-brain barrier antibody cavernous sinus BBB–peptide shuttle brain delivery solute carrier (SLC) transporters amyotrophic lateral sclerosis (ALS) NSC-34 cell lines taurine transporter (Taut) large amino acid transporter 1 (LAT1) monocarboxylate transporters (MCTs) organic cation transporters (OCTNs) choline transporter-like protein-1 (CTL1) TNF-α inhibitor molecular Trojan horse endosomal liposome nanoparticle targeting transferrin n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20230202_9783036564173_130 |