From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder
Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become...
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| Μορφή: | Online |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Διαθέσιμο Online: | 25389 |
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| _version_ | 1869515059479183360 |
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| author | Carlo Catassi (Ed.) Alessio Fasano (Ed.) |
| author_browse | Alessio Fasano (Ed.) Carlo Catassi (Ed.) |
| author_facet | Carlo Catassi (Ed.) Alessio Fasano (Ed.) |
| author_sort | Carlo Catassi (Ed.) |
| collection | Directory of Open Access Books |
| description | Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented. |
| format | Online |
| id | doab-20.500.12854ir-48117 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-481172024-03-30T23:21:42Z From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder Carlo Catassi (Ed.) Alessio Fasano (Ed.) R5-920 gluten-related disorders；celiac disease；gluten intolerance thema EDItEUR::M Medicine and Nursing Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented. 2021-02-11T14:08:03Z 2021-02-11T14:08:03Z 2018-02-16 09:08:33 2018 book 25389 9783038427322 9783038427315 https://directory.doabooks.org/handle/20.500.12854/48117 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International http://www.mdpi.com/books/pdfview/book/538 http://www.mdpi.com/books/pdfview/book/538 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03842-732-2 10.3390/books978-3-03842-732-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038427322 9783038427315 VIII, 230 open access |
| spellingShingle | R5-920 gluten-related disorders；celiac disease；gluten intolerance thema EDItEUR::M Medicine and Nursing Carlo Catassi (Ed.) Alessio Fasano (Ed.) From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder |
| title | From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder |
| title_full | From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder |
| title_fullStr | From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder |
| title_full_unstemmed | From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder |
| title_short | From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder |
| title_sort | from ptolemaus to copernicus the evolving system of gluten related disorder |
| topic | R5-920 gluten-related disorders；celiac disease；gluten intolerance thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 gluten-related disorders；celiac disease；gluten intolerance thema EDItEUR::M Medicine and Nursing |
| url | 25389 |
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