Chapter Bioreactor-Based Bone Tissue Engineering
Omega-3 (ω-3) and omega-6 (ω-6) are polyunsaturated fatty acids (PUFAs) that play critical role in human health and have to be provided by food. In the brain, PUFAs are also precursors of endocannabinoids. The aim of this chapter is to review the existing literature on how dietary PUFAs impact on th...
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| Format: | Online |
| Idioma: | anglès |
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InTechOpen
2021
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| Accés en línia: | ONIX_20210602_10.5772/62546_261 |
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| author | Marijanovic, Inga Antunovic, Maja Matic, Igor Panek, Marina Ivkovic, Alan |
| author_browse | Antunovic, Maja Ivkovic, Alan Marijanovic, Inga Matic, Igor Panek, Marina |
| author_facet | Marijanovic, Inga Antunovic, Maja Matic, Igor Panek, Marina Ivkovic, Alan |
| author_sort | Marijanovic, Inga |
| collection | Directory of Open Access Books |
| description | Omega-3 (ω-3) and omega-6 (ω-6) are polyunsaturated fatty acids (PUFAs) that play critical role in human health and have to be provided by food. In the brain, PUFAs are also precursors of endocannabinoids. The aim of this chapter is to review the existing literature on how dietary PUFAs impact on the endocannabinoid system in the brain and what are the consequences for brain function and dysfunction. In this chapter, we will first describe how PUFAs enter the brain, what are their metabolism processes and roles in brain function. We will describe the pathways from PUFAs to endocannabinoid production. Then, we will review the literature on how dietary ω-6/ω-3 ratio impacts the endocannabinoid system, in terms of endocannabinoid levels, proteins and endocannabinoid-dependent synaptic plasticity. In the next part, we will describe what we know about the interactions between PUFAs and endocannabinoids in neurological and neuropsychiatric disorders. Finally, we will conclude on the possible implications of the interactions between dietary PUFAs and endocannabinoids in the normal and pathological brain. In particular, we will discuss how dietary PUFAs, as homeostatic regulators of endocannabinoids, can constitute interesting therapeutic strategies for the prevention and/or treatment of neurological disorders with endocannabinoids impairment. |
| format | Online |
| id | doab-20.500.12854ir-70242 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-702422024-04-01T14:15:03Z Chapter Bioreactor-Based Bone Tissue Engineering Marijanovic, Inga Antunovic, Maja Matic, Igor Panek, Marina Ivkovic, Alan brain, polyunsaturated fatty acids, endocannabinoids, omega-3, synaptic plasticity thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Omega-3 (ω-3) and omega-6 (ω-6) are polyunsaturated fatty acids (PUFAs) that play critical role in human health and have to be provided by food. In the brain, PUFAs are also precursors of endocannabinoids. The aim of this chapter is to review the existing literature on how dietary PUFAs impact on the endocannabinoid system in the brain and what are the consequences for brain function and dysfunction. In this chapter, we will first describe how PUFAs enter the brain, what are their metabolism processes and roles in brain function. We will describe the pathways from PUFAs to endocannabinoid production. Then, we will review the literature on how dietary ω-6/ω-3 ratio impacts the endocannabinoid system, in terms of endocannabinoid levels, proteins and endocannabinoid-dependent synaptic plasticity. In the next part, we will describe what we know about the interactions between PUFAs and endocannabinoids in neurological and neuropsychiatric disorders. Finally, we will conclude on the possible implications of the interactions between dietary PUFAs and endocannabinoids in the normal and pathological brain. In particular, we will discuss how dietary PUFAs, as homeostatic regulators of endocannabinoids, can constitute interesting therapeutic strategies for the prevention and/or treatment of neurological disorders with endocannabinoids impairment. 2021-02-10T12:58:18Z 2021-06-02T10:07:50Z 2016 chapter ONIX_20210602_10.5772/62546_261 https://library.oapen.org/handle/20.500.12657/49147 https://directory.doabooks.org/handle/20.500.12854/70242 eng open access image/jpeg image/jpeg image/jpeg n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/49147/1/50291.pdf https://library.oapen.org/bitstream/20.500.12657/49147/1/50291.pdf https://library.oapen.org/bitstream/20.500.12657/49147/1/50291.pdf InTechOpen 10.5772/62546 10.5772/62546 035ecc65-6737-43cf-a13a-6bdf67ce01f4 open access |
| spellingShingle | brain, polyunsaturated fatty acids, endocannabinoids, omega-3, synaptic plasticity thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Marijanovic, Inga Antunovic, Maja Matic, Igor Panek, Marina Ivkovic, Alan Chapter Bioreactor-Based Bone Tissue Engineering |
| title | Chapter Bioreactor-Based Bone Tissue Engineering |
| title_full | Chapter Bioreactor-Based Bone Tissue Engineering |
| title_fullStr | Chapter Bioreactor-Based Bone Tissue Engineering |
| title_full_unstemmed | Chapter Bioreactor-Based Bone Tissue Engineering |
| title_short | Chapter Bioreactor-Based Bone Tissue Engineering |
| title_sort | chapter bioreactor based bone tissue engineering |
| topic | brain, polyunsaturated fatty acids, endocannabinoids, omega-3, synaptic plasticity thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | brain, polyunsaturated fatty acids, endocannabinoids, omega-3, synaptic plasticity thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20210602_10.5772/62546_261 |
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